不同剂量缬沙坦对冠状动脉介入术后患者血清中PPARγ含量及机体炎症程度的影响  

Effects of different doses of valsartan on serum PPARγ levels and degree of inflammation after percutaneous coronary intervention

作　　者：陈维[1] 

机构地区：[1]四川省成都市第五人民医院急诊科,四川成都611130

出　　处：《海南医学院学报》2016年第20期2401-2404,共4页Journal of Hainan Medical University

基　　金：四川省卫生厅科研项目(130259)~~

摘　　要：目的:研究不同剂量缬沙坦对冠状动脉介入术后患者血清中PPARγ含量及机体炎症程度的影响。方法:选择在我院接受经皮冠状动脉介入术(PCI)治疗的148例冠心病患者并随机分为高剂量组和低剂量组,分别接受围手术期160mg/d和40mg/d的缬沙坦口服治疗。手术前1d和手术后1、2、4周时,测定外周血单个核细胞中PPARγ的含量;手术后4周时,测定血清中PPARγ相关分子的含量。结果:手术后1、2、4周时,高剂量组外周血单个核细胞中PPARγ的mRNA含量和蛋白含量均明显高于低剂量组(P<0.05);治疗后4周时,高剂量组血清中MCP-1、MMP-9、E-selectin、P-selectin、IL-6、TNF-α、Fas、FasL、Caspase-3、Bax、Resistin、Betatrophin的含量明显低于低剂量组,Apelin、Adiponectin、Adropin的含量显著高于低剂量组。结论:160mg/d缬沙坦治疗能够通过抑制PCI术后PPARγ的表达来减少炎性因子和凋亡分子的分泌、增加胰岛素敏感性、减轻胰岛素抵抗。Objective：To investigate the effects of different doses of valsartan on serum PPARγlevels and degree of inflammation after percutaneous coronary intervention.Methods：A total of 148 patients with coronary heart disease who received percutaneous coronary intervention（PCI）in our hospital were selected and randomly divided into high dose group and low dose group who received perioperative oral administration of 160mg/d and 40mg/d of valsartan respectively.1dbefore operation as well as 1week,2weeks and 4weeks after operation,the levels of PPARγin peripheral blood mononuclear cells were determined;4weeks after operation,serum levels of PPARγ-related molecules were determined.Results：1week,2weeks and 4weeks after undergoing the operation,PPARγmRNA levels and protein levels in peripheral blood mononuclear cells of high dose group were significantly higher than those of low dose group（P〈0.05）;4weeks after treatment,serum MCP-1,MMP-9,E-selectin,P-selectin,IL-6,TNF-α,Fas,FasL,Caspase-3,Bax,Resistin and Betatrophin levels of high dose group were significantly lower than those of low dose group while Apelin,Adiponectin and Adropin levels were significantly higher than those of low dose group.Conclusion：160mg/d of valsartan treatment can inhibit the PPARγexpression after PCI so as to re-duce the secretion of inflammatory factors and apoptotic molecules,increase insulin sensitivity and reduce insulin resistance.

关 键 词：冠状动脉介入术 缬沙坦 过氧化物酶体增殖物激活受体Γ 炎症反应 凋亡 

分 类 号：R541.4[医药卫生—心血管疾病]