冠心舒通胶囊治疗冠心病心绞痛有效性及安全性的Meta分析  

A Meta-Analysis of Guanxin Shutong Capsule on Patients with Unstable Angina

作　　者：隋竞仪 徐卉[1] 秦玲[1] 徐国良[1] SUI Jingyi XU Hui QIN Ling et al(The Eastern Division of the First Hospital of Jilin University,Jilin,Changehun 130031 ,China)

机构地区：[1]吉林大学第一医院二部,吉林长春130031

出　　处：《中国中医急症》2016年第10期1863-1865,1893,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：吉林省科技厅项目(200905138)

摘　　要：目的 应用Meta分析的方法分析冠心舒通胶囊治疗冠心病心绞痛的有效性及安全性。方法 电脑查阅Cochrane试验资料库（2016年第1期）、Embase（1966年至2016年3月）、Pubmed（1966年至2016年3月）、中国学术文献总库（CNKI）（1979年至2016年3月）、中文科技期刊数据库（1989年至2016年3月）、万方数字期刊库（1981年至2016年3月）,根据入选与剔除原则筛选文献、评价文献质量,从文献中提取相关数据,应用RevMan 5.3软件对提取的数据进行Meta分析。结果 初步检索出194篇文献,根据选取标准共有12文献符合。从症状疗效来分析：χ~2=10.45,df=11,P=0.49,合并OR=2.58,95%CI[1.99,3.34],Z=7.20（P〈0.00001）;从心电图疗效来分析：χ~2=10.45,df=11,P=0.49,合并OR=2.48,95%CI[1.95,3.17],Z=7.33（P=0.00001）。结论 冠心舒通胶囊治疗冠心病心绞痛在缓解症状及改善心电图方面效果更好,无明显不良反应。Objective： To approach the efficacy and safety of Guanxin Shutong Capsule in treating patients with unstable angina （UA）. Methods： The Cochrane Central Register of Controlled Trials （Issuel, 2016）, EMbase （1966 to March 2016）,Pubmed （1966 to March 2016）,CNKI （1979 to March 2016）,CBM （1989 to March 2016） ,WanFang （1981 to March 2016） were searched. We also hand searched relevant journals and conference proceedings. Randomized controlled trials （RCTs） in which Guanxinning Injection was used to treat patients with UA were collected.Then we screened the retrieved studies according to prcdefined inclusion and exclusion criteria,evaluated the quality of included studies,and performed Meta analyses by using RevMan 5.3 software. Therapeutic effects of angina peetoris and efficacy of electrocardiogram （ECG） were selected as the study indices. Re- sults： A total of 194 articles were found and 12 of which were finally included. Therapeutic effects of angina pectoris were selected as the study indices,X^2=10.45,df=11 ,P=0.49,OR=2.58,95%CI [1.99,3.34] ,Z= 7.20 （P〈 0.00001 ）. ECG were selected as the study indices,X^2=10.45 ,df=11,P=0.49,OR=2.48,95%CI [1.95,3.17] ,Z= 7.33 （P= 0.00001 ）. Conclusion： Guanxin Shutong Capsule is effective and safe to treat patients with unstable angina.

关 键 词：冠心舒通胶囊 冠心病 心绞痛 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]