中西医结合治疗无菌性股骨头坏死186例疗效及相关指标的研究  

Combine Traditional Chinese and Western Medicine Treatment the Curative Effect of 186 Cases of Aseptic Necrosis of Femoral Head and the Study of Related Indicators

作　　者：吴效普[1] 张勇[1] 

机构地区：[1]菏泽医学专科学校,山东菏泽274000

出　　处：《菏泽医学专科学校学报》2016年第3期42-44,54,共4页Journal of Heze Medical College

摘　　要：目的探讨中西医结合治疗无菌性股骨头坏死的疗效及相关指标的变化。方法将无菌性股骨都坏死患者186例,193个髋关节。进行中西医结合治疗。西药给予654-2、CO丹参、刺五加、维生素E、左旋咪唑、丹参酮。中草药日一剂。绝对制动。3个月为一个疗程,治疗前后检测血脂、血流变学及瘦素变化。所获数据采用方差分析、t检验和X^2检验。结果经过3个月的规范治疗,治愈127髋,占65.80%。显效63髋,占32.64%。有效3髋,占1.55%。治疗前后总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白比较t=21.52~102.56,P均<0.001,有非常显著性差异。全血黏度、全血高切黏度、低切血浆黏度、红细胞压积、血沉治疗前后比较,t=8.68~40.306,P均<0.001,有非常显著性差异。不同性别及整体瘦素治疗前后比较,t=4.1936~12.736,P均<0.001,有非常显著性差异。服药后有腹泻149例,占80.11%。多在1个月内自行终止,有4例服药后3个月还有腹泻。结论股骨头坏死中早期不要急于手术治疗。中西医结合治疗是从分子水平到临床多层面、多靶点发挥作用,效果理想,值得推广。剂型有待于进一步研究改进。Objective To explore the curative effect of combined traditional Chinese and western medicine treatment of aseptic necrosis of femoral head and the related indicators of change. Methods 186 patients with aseptic necrosis femoral all, 193 of the hip. Combine traditional Chinese and western medicine therapy. Western medicine for 654-2, Compound salvia miltiorrhiza, acanthopanax, vitamin E, levamisole, tanshinone. Chinese herbal medicine, a dose. Absolute braking. 3 months for a period of treatment, detection of blood lipids, before and after the treatment on hemorrheology and leptin changes. The data obtained using analysis of variance, t test and χ2 test. Results After 3 months of standard treatment, to cure 127 hip, accounting for 65.80%. ＊ 63 hip, accounting for 32.64%. Effective 3 hips, accounting for 1.55%. Before and after treatment the total cholesterol, triglycerides, high-density lipoprotein cholesterol （hdl-c）, low density lipoprotein is t= 21.52 - 102.56, P〈 0.001. There is a very significant difference. Whole blood viscosity, whole blood high shear viscosity, plasma viscosity, erythrocyte pressure low cut and blood sedimentation, compared before and after treatment, t= 8.68 - 8.68, P〈 0.001. There is a very significant difference. Different gender and overall leptin compared before and after treatment, t= 4.1936 - 4.1936, P〈 0.001. There is a very significant difference. After taking medicine, 149 cases of diarrhea, accounting for 80.11%. Terminate itself in 1 month, 4 cases of 3 months and diarrhea after taking this medicine. Conclusion Early femoral head necrosis in don＇t rush to surgery. Combine traditional Chinese and western medicine treatment from molecular level to the clinical level, target function, ideal effect, is worth promoting. Dosage form needs to be further research to improve.

关 键 词：股骨头坏死 无菌性 中西医结合疗法 血流变学 血脂 瘦素 

分 类 号：R681.8[医药卫生—骨科学] R2-031[医药卫生—外科学]