间苯三酚联合山莨菪碱治疗下尿路微创手术后膀胱痉挛的疗效观察  

A study on the curative effect of phloroglucinol combined with anisodamine on bladder spasm after minimally invasive surgery of urinary tract

作　　者：崔国兴[1] 崔国旺 杨磊[1] 石艳波[1] 李世俊[1] 

机构地区：[1]涿州市医院泌尿外科,河北保定072750 [2]保定市第二中心医院,河北保定071000

出　　处：《现代泌尿外科杂志》2016年第10期790-792,共3页Journal of Modern Urology

基　　金：2015年保定市科学技术研究与发展指导计划项目(No.15ZF063)

摘　　要：目的 探究间苯三酚联合山莨菪碱治疗下尿路微创手术后用膀胱痉挛的疗效。方法 选取我院2014年1月至2015年1月下尿路微创手术患者204例,按照随机数表法分为实验组（51例）、山莨菪碱组（51例）和M阻滞剂组（51例）和间苯三酚组（51例）,实验组为接受间苯三酚联合山莨菪碱治疗的患者,山莨菪碱组接受山莨菪碱治疗,M阻滞剂组仅接受M受体阻滞剂治疗,间苯三酚组仅接受间苯三酚治疗,分别在用药后0～24、25～48和49～72h三个时间段内记录四组患者膀胱痉挛发生次数、持续时间及疼痛程度。结果 四组患者用药后各时间段膀胱痉11挛发生次数显示：实验组在用药后0～24h、25～48h、49～72h发生次数分别为（7.12±0.33）、（4.75±0.35）、（3.23±0.53）次,实验组分别与其他三组患者对应时间段相比较差异有统计学意义（P〈0.05）;实验组用药后痉挛持续时间分别为（0.75±0.13）、（0.62±0.21）、（0.52±0.33）h,而山莨菪碱组为（1.57±0.32）、（1.09±0.23）、（0.86±0.41）h,M阻滞剂组分别为（1.43±0.19）、（1.01±0.32）、（0.79±0.30）h,间苯三酚组分别为（1.43±0.19）、（1.01±0.32）、（0.79±0.30）,实验组分别与其他三组患者对应时间段相比较差异有统计学意义（P〈0.05）;实验组患者3个时间段内用疼痛VAS评分分数分别为（3.65±0.78）分、（3.12±0.56）分、（2.67±0.34）分,实验组分别与其他三组对应时间段相比较,差异有统计学意义（P〈0.05）。结论 用间苯三酚联合山莨菪碱治疗下尿路微创手术后膀胱痉挛,可减少膀胱痉挛发生次数和时间,并且减轻患者疼痛程度。Objective To explore the curative effect of phloroglucinol combined with anisodamine on bladder spasm af- ter minimally invasive surgery of urinary tract. Methods A total of 204 patients who received minimally invasive surgery of urinary tract in our hospital during Jan. 2014 and Jan. 2015 were involved and randomly divided into the experimental group （ n = 51, receiving phloroglucinol combined with anisodamine）, anisodamine group （n=51, receiving anisodamine）, M receptor antagonist group （n= 51, receiving M receptor antagonist） and phloroglucinol group （n = 51, receiving phloroglucinol）. At 0-24 h, 24-48 h, and 48-72 h after medication, bladder spasm frequency, duration and degree of pain of each group were recorded. Results During the three periods, the occurrence of bladder spasm in the experimental group was （7.12±0.33）, （4.75±0.35）, （3.23±0.53）, and there was statistically significant difference between the experimental group and the other three groups （P～0.05）. During the three periods, the duration of bladder spasm in the experimental group was （0.75± 0.13）, （0.62±0.21）, （0.52±0.33） h, that of the anisodamine group was （1.57±0.32）, （1.09±0.23）, （0.86±0.41） h, that of the M receptor antagonist group was （1.43±0.19）, （1.01±0.32）, （0.79±0.30） h, that of the phloroglucinol group was （1.43±0.19）, （1.01±0.32）, （0.79±0.30） h, and there was statistically significant difference between the experimental group and the other three groups （P〈0.05）. The pain VAS score in the experimental group was （3.65±0.78）, （3. 12±0.56）, （2.67±0.34）, and there was statistically significant difference between the experimental group and the other three groups （P〈0.05）. Conclusion Phloroglucinol combined with anisodamine to treat bladder spasm after minimally invasive surgery of urinary tract can reduce the occurrence and duration of bladder spasm and relieve the pain of patients.

关 键 词：间苯三酚 山莨菪碱 M受体阻滞剂 下尿路 膀胱痉挛 

分 类 号：R69[医药卫生—泌尿科学]