奥美拉唑治疗小儿消化道出血的临床疗效  

The clinical efficacy of omeprazole for treatment of infantile gastrointestinal hemorrhage

作　　者：周巍玲 汤淑斌[2] 黎建丽[1] 

机构地区：[1]宝鸡市妇幼保健院儿童医院儿二科,陕西宝鸡721000 [2]宝鸡市妇幼保健院儿童医院院办,陕西宝鸡721000

出　　处：《热带医学杂志》2016年第9期1168-1170,共3页Journal of Tropical Medicine

摘　　要：目的探讨奥美拉唑治疗小儿消化道出血的临床疗效。方法选取宝鸡市妇幼保健院儿童医院2013年3月至2015年3月收治的100例小儿消化道出血患儿作为研究对象,随机分为对照组和观察组,每组患儿50例。两组患儿均给予支持、补液治疗。对照组患儿给予西咪替丁治疗,观察组患儿给予奥美拉唑治疗,对比治疗后两组患儿的临床疗效和不良反应。结果观察组患儿止血时间、住院时间和腹部不适症状消失时间分别为(1.02±0.49)、(4.78±1.53)和(1.02±0.31)d,均显著短于对照组的(2.48±1.31)、(7.15±1.62)和(2.05±1.15)d,差异有统计学意义(P1=0.002,P2=0.001,P3=0.000)。观察组患儿治疗总有效率为92%,高于对照组的74%,差异有统计学意义(P4=0.006)。治疗期间无不良反应出现。结论奥美拉唑用于治疗小儿消化道出血的临床疗效显著,值得推广使用。Objective To study the clinical effect of omeprazole for the treatment of infantile gastrointestinal hemorrhage.Methods 100 patients with infantile gastrointestinal hemorrhage selected in Children＇s Hospital of Baoji Maternal and Child Health Care Hospital from March 2013 to March 2015 were randomly divided into control group and observation group,50 cases in each group. The control group was given cimetidine treatment while the experimental group was given omeprazole treatment. Efficacy and adverse reaction were compared between two groups. Results Hemostasis time,hospitalization days and symptom disappearance time of the control group were（2.48 ±1.31）,（7.15 ±1.62） and（2.05 ±1.15）d, while those of the observation group were（1.02 ±0.49）,（4.78 ±1.53） and（1.02 ±0.31）d. The differences between two groups were statistically significant（P1=0.002,P2=0.001,P3=0.000）. The total effective rate of clinical treatment in the control group and observation group was 74% and 92%, respectively. The differences between two groups were statistically significant（P4=0.006）. Conclusion Omeprazole is effective for the treatment of infantile gastrointestinal hemorrhage and it has clinical application value.

关 键 词：奥美拉唑 西咪替丁 小儿消化道出血 临床疗效 

分 类 号：R725.7[医药卫生—儿科]