急性ST段抬高型心肌梗死患者血液中性粒细胞/淋巴细胞比值、内皮细胞特异性分子-1水平与近期预后的关系  

Relationship between neutrophil to lymphocyte ratio and endothelial cell specific molecule-1 level and short-term prognosis in patients with acute ST-segment elevation myocardial infarction

作　　者：邱崇荣 付强[2] 眭建[1] 张倩[2] 魏鹏[2] 朱可[2] 陆奕[2] 万鹏[1] QIU Chong-rong FU Qiang SUI Jian ZHANG Qian WEI Peng ZHU Ke LU Yi WAN Peng(School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013 Department of Cardiology, Xuzhou Central Hospital, Xuzhou Jiangsu 221009, China)

机构地区：[1]江苏大学医学院,江苏镇江212013 [2]徐州市中心医院心内科,江苏徐州221009

出　　处：《江苏大学学报（医学版）》2016年第1期61-64,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的：探讨ST段抬高型心肌梗死（ST-segment elevation myocardial infarction,STEMI）患者血液中性粒细胞/淋巴细胞比值（neutrophil to lymphocyte ratio,NLR）、内皮细胞特异性分子-1（endothelial cell specific molecule-1,ESM-1）水平及与近期预后的关系。方法：序贯入选急性STEMI患者105例,同时纳入健康成年对照组33例,比较两组NLR、ESM-1水平差异,并记录STEMI患者住院期间及出院后3个月主要不良心血管事件（major adverse cardiovascular events,MACE）。Logistic回归分析MACE发生的危险因素。结果：STEMI组NLR、ESM-1水平明显高于对照组（P=0.00）。相关性分析表明,NLR与TIMI积分（r=0.19,P=0.04）,肌钙蛋白（r=0.26,P=0.01）呈正相关。单因素Logistic回归显示,NLR（OR：1.095,95%CI：1.0211.175,P=0.01）、ESM-1〉1.01μg/L（OR：3.011,95%CI：1.0498.642,P=0.04）、年龄（OR：1.044,95%CI：1.0081.082,P=0.02）、HDL-C（OR：6.692,95%CI：1.69526.426,P=0.01）、LDL-C（OR：1.701,95%CI：1.1482.522,P=0.01）、TIMI评分（OR：1.408,95%CI：1.1641.704,P=0.00）为MACE发生的危险因素。多因素Logistic回归显示NLR（OR：1.113,95%CI：1.0261.207,P=0.01）、ESM-1〉1.01μg/L（OR：3.543,95%CI：1.07911.632,P=0.04）为MACE发生的危险因素。结论：STEMI患者NLR、ESM-1浓度〉1.01μg/L可能对发生MACE具有预测价值。Objeetive： To investigate the relationship between neutrophil to lymphocyte ratio（NLR） and endothelial cell specific molecule-1 （ ESM-1 ） level in patients with acute ST-segment elevation myocardial infarction（STEMI）. Methods： A total of 105 patients with STEMI and 33 individuals as a control group were included in the study. The level of NLR and ESM-1 were analyzed in two groups. The patients with STEMI were followed-up for three months, and major adverse cardiovascular events （MACE） was recorded. Logistic regression analysis was used to analyze the risk factor for MACE. Results ： Compared to the control group, NLR and serum ESM-1 level were significantly higher in patients with STEMI （ P =0.00）. In these patients,NLR were positive correlated with TIMI risk score and troponin （r = 0.19, P = 0.04 ; and r = 0.26, P = 0.01, respectively）. Univariate Logistic regression analysis indicated that NLR [odds ration （OR）： 1.095,95% confidence interval（CI）： 1.021 -1.175, P=0.01],ESM-1 〉1.01 μg/L （OR： 3.011,95% CI：1.049-8.642, P=0.04）,age （OR：1.044,95% CI： 1.008 -1.082, P=0.02）,HDL- C（OR： 6. 692,95%, CI： 1. 695 - 26. 426, P =0.01）,LDL-C（OR：1.701,95% CI：1.148-2.522,P =0. 01 ） ,TIMI risk seore（OR：1.408,95% CI：1. 164 - 1.704, P =0.00） were the predictors of MACE. Multi- variate Logistic regression analysis indicated that NLR（ OR： 1. 113,95% CI： 1. 026 - 1. 207, P = 0.01 ） ,ESM-1 level 〉 1.01 μg/L （ OR：3. 543,95% CI： 1. 079 - 11. 632, P =0.04） were the predictors of MACE. Conclusion： NLR and an ESM-1 level 〉 1.01 μg/L were likely to predict a greater risk of MACE in patients with STEMI.

关 键 词：急性ST段抬高型心肌梗死 中性粒细胞/淋巴细胞比值 内皮细胞特异性分子-1 主要不良心血管事件 

分 类 号：R542.22[医药卫生—心血管疾病]