龙牛壮骨膏质量控制初步研究  

Study on Quality Control of Longniu Zhuanggu Cream (龙牛壮骨膏)

作　　者：王秉隆 郭金峰 迟敬涛 丁传华[3,4] 李义清[3,4] 李万忠[4] 

机构地区：[1]高密市中医院,山东潍坊261501 [2]高密市醴泉街道康庄卫生院,山东潍坊261512 [3]山东医药卫生临床应用药理学重点实验室,山东潍坊261000 [4]潍坊医学院,山东潍坊261053

出　　处：《中医药导报》2016年第20期55-61,共7页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：潍坊市科技发展计划项目(No.2013yd144)

摘　　要：目的:多手段分析龙牛壮骨膏中化学成分,为其质量控制研究提供理论依据。方法:采用TLC法对龙牛壮骨膏处方主要药物进行定性鉴别;借助FTIR、GC-MS、PY-GC/MS、HS/GC/MS、EDS、XRD、TGA分析检测龙牛壮骨膏中化学成分。结果:样品的软化点为56.9℃。龙牛壮骨膏中初步检出粗蛋白1.16%,油脂63.29%,乳香2.56%,维生素A 0.15%,氢氧化铝9.95%,二氧化硅14.93%,没药2.82%,杜仲1.55%,D-樟脑0.34%,冰片3.25%。结论:TLC法简单可行,重复性好,斑点清晰;不同分析方法表征龙牛壮骨膏中化学成分,为下一步该制剂的剂型改革奠定应用基础,为外用膏药的质量控制研究提供借鉴。Objective： To analyze the composition of Longniu Zhuanggu Cream, in order to provide the basis for quality standard research. Methods： The TLC method was used to identify the drug of Longniu Zhuanggu Cream; The chemical constituents of Longniu Zhuanggu Cream were detected by FTIR, GC-MS, PY-GC/MS, HS/ GC/MS, EDS, XRD and TGA. Results： The softening point of the sample is 56.9℃. Preliminary detection showed crude protein1.16%, fat 63.29%, frankincense 2.56%, vitamin A 0.15%, aluminum hydroxide 9.95%, silica14.93%, myrrh 2.82%, Eucommia ulmoides 1.55%, d-camphor 0.34% and borueol 3.25%. Conclusion： TLC method is simple, feasible and reproducible, and the spots are clear. A variety of means of bull for a more comprehensive analysis and lay the foundation for improved the formulation and quality control, to provide a reference for external use plaster preparation research.

关 键 词：龙牛壮骨膏 TLC法 FTIR GC-MS XRD TGA 

分 类 号：R284[医药卫生—中药学]