高压氧对急诊PCI术后患者Hs-CRP和ET-1的影响  

Influence by hyperbaric oxygen on Hs-CRP and ET-1 in patients after emergency PCI

作　　者：耿银东[1] 范萍[1] 卢革新[1] 

机构地区：[1]郑州市第二人民医院心内科,450000

出　　处：《中国现代药物应用》2016年第19期27-28,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨高压氧对急诊经皮冠状动脉介入治疗(PCI)术后患者超敏C反应蛋白(Hs-CRP)和内皮素-1(ET-1)的影响。方法 85例急性心肌梗死(AMI)行急诊PCI术患者,随机分为对照组(43例)和治疗组(42例)。对照组术后给予常规药物治疗,治疗组在常规治疗基础上于术后病情相对稳定72 h后行高压氧治疗,两组患者于术后第2天和高压氧治疗结束后清晨检测Hs-CRP和ET-1。结果治疗后,治疗组和对照组Hs-CRP(7.88±1.78)、(9.96±2.10)mg/L和ET-1(45.21±12.38)、(65.12±18.11)ng/L水平均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。结论高压氧治疗可以改善血管内皮功能,减轻局部炎症反应,对于预防急诊PCI术后早期支架内血栓有一定临床意义。Objective To investigate influence by hyperbaric oxygen on high-sensitivity C-reactive protein（Hs-CRP） and endothelin-1（ET-1） in patients after emergency percutaneous coronary intervention（PCI）. Methods A total of 85 acute myocardial infarction（AMI） patients receiving PCI were randomly divided into control group（43 cases） and treatment group（42 cases）. The control group received conventional drug therapy, and the treatment group received additional hyperbaric oxygen therapy after 72 h of stable state. Both groups received Hs-CRP and ET-1 detection in postoperative 2 d and after hyperbaric oxygen therapy. Results After treatment, both treatment group and control group had lower Hs-CRP as（7.88±1.78） and（9.96±2.10） mg/L and ET-1 as（45.21±12.38） and（65.12±18.11）ng/L than those before treatment, and the treatment group had lower levels than the control group. Their differences all had statistical significance（P〈0.05）. Conclusion Hyperbaric oxygen therapy can improve vascular endothelial function and relieve partial inflammatory reaction. This method contains certain clinical significance for preventing early stent thrombosis after emergency PCI.

关 键 词：高压氧 经皮冠状动脉介入治疗 超敏C反应蛋白 内皮素-1 

分 类 号：R541.4[医药卫生—心血管疾病]