hUC-MSCs肝样细胞分化机制的研究进展  

Progress in the Mechanisms of hUC-MSCs Differentiation into Hepatocyte-like Cells

作　　者：彭琴[1] 张蕾[2] 

机构地区：[1]昆明医科大学,昆明650500 [2]昆明医科大学附属甘美医院/昆明市第一人民医院,昆明650011

出　　处：《中国细胞生物学学报》2016年第9期1134-1143,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81660303);云南省科技厅–昆明医科大学联合专项资助的课题~~

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)是来源于发育早期中胚层的一类多能干细胞,广泛分布于全身结缔组织和器官间质中,是一类具有自我更新、不断增殖和多向分化潜能的成体干细胞。随着组织工程和再生医学的研究和发展,MSCs成为一种治疗各种终末期肝脏疾病的潜在治疗手段。该文就人脐带间充质干细胞(human umbilicalcord mesenchymal stem cells,h UCMSCs)的生物学特性、体外诱导分化为肝样细胞(hepatocyte-like cells,HLCs)及其可能分化机制的研究进展予以综述。Mesenchymal stem cells（MSCs） is a class of mesodermal multipotent stem cells, which are derived from the early developmental mesoderm. They widely distributed in connective tissues and organ stroma with characteristics of continuous self-renewal, proliferation and multipotential differentiation. With the progress of study in tissue engineering and regenerative medicine, MSCs have become a potential therapeutic tool for the treatment of various end-stage liver disease. Here, we reviewed the progress in biological characteristics of human umbilical cord mesenchymal stem cells（h UC-MSCs）, their differential ability into hepatocyte-like cells, as well as its possible mechanisms.

关 键 词：脐带间充质干细胞 肝细胞样分化 信号通路 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]