唑菌酯原药大鼠致畸毒性试验  

Teratogenicity Test of Pyraoxystrobin TC on Rat

作　　者：韦春晟 廖雪 鲍清 

机构地区：[1]国家沈阳新药安全评价研究中心,沈阳110021

出　　处：《农药》2016年第10期760-761,773,共3页Agrochemicals

摘　　要：[目的]测定唑菌酯原药对大鼠致畸方面的影响。[方法]应用Sprague Dawley(SD)大鼠为试验动物,设计5、15、45 mg/kg b.w.3个剂量组和1个阴性对照组来测定唑菌酯原药对动物致畸的影响。[结果]大鼠经口灌胃给予唑菌酯原药15、45 mg/kgb.w.两个剂量组动物和对照组动物相比,出现显著性的体质量增长缓慢;各剂量组胎鼠体质量也出现增长缓慢。[结论]经口灌胃给药15 mg/kgb.w.时,对孕鼠体质量增长有影响;给药5 mg/kg时,对胎仔的生长速度有影响;但并无致畸作用。[Aims ] The potential embryonal toxicity and teratogenic effects of pyraoxystrobin TC on Sprague Dawley rat were determined. [Methods ] The three groups of rats were orally administered and gavage with pyraoxystrobin at 5, 15 and 45 mg/kg b.w. continuously for 14 days from 6 th to 19 th day after gestation. In addition, the rats of negative control were orally administered with sodium carboxymethyl cellulose solution at 0.5%（w/v） were performed as the same time.[Results] Compared to the rats of negative control, when the rats were orally administered with pyraoxystrobin at 15 and45 mg/kg b.w., the the weight gain of the pregnant rats was signifycantly lower. In addition, weight gain of the fetus was signifycantly lower（P0.001）. [Conclusions] When the rats were orally administered with pyraoxystrobin at 15 mg/kg b.w,the weight gain of the pregnant rats was affected. When the dose was 5 mg/kg, the growth rate of the fetus was affected,however, there was no teratogenic effect on rats.

关 键 词：唑菌酯 原药 大鼠 胚胎毒性 致畸作用 

分 类 号：TQ450.261[化学工程—农药化工]