脑死亡与心死亡后器官捐献成人供受者单肾移植效果比较  

Comparison the outcome of donation after brain death and cardiac death for adult-to-adult single kidney transplantation

作　　者：黄焕文[1] 刘丁[1] 胡建敏[1] 陈桦[1] 李民[1] 李留洋[1] 郭颖[1] 赵明[1] HUANG ttuan-wen LIU Ding HU Jian-min CHEN Hua LI Min LI Liu-yang GUO Ying ZHAO Ming.(Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China)

机构地区：[1]南方医科大学珠江医院器官移植科,广州市510280

出　　处：《实用医学杂志》2016年第18期3011-3014,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81170696)

摘　　要：目的：比较脑死亡与心死亡后器官捐献成人供受者单肾移植疗效。方法：回顾性分析我院2012年10月至2015年9月成人供受者单肾移植的临床疗效：脑死亡捐献肾移植（DBD组）53例及心死亡肾移植（DCD组）28例,截止随访时间为2016年5月。结果：研究期间,随访时间为（17.26±10.85）个月,移植人存活率为100%,两组总体移植肾存活率DBD组为93.7%,DCD组为92%,差异无统计学意义（P〉0.05）,总体DGF发生率为28.4%,组间DGF发生率（χ~2=4.402,P=0.036）、1年内感染率（χ~2=4.507,P=0.034）差异有统计学意义（P〈0.05）;组间AR、术后1个月e GFR、1个月蛋白尿、外科并发症比较,差异均无统计学意义（P〉0.05）。结论：心死亡器官捐献成人供受者单肾移植有较高的DGF及1年内感染发生率,心死亡后器官捐献肾移植有较好的疗效。Objective To compare the outcome of adult-to-adult single kidney transplantation from donation after drain death and cardiac death. Methods The outcome of aduh-to-aduh single kidney transplantation from October 2012 to September 2015 in kidney transplantation center of Zhujiang Hospital was retrospectively analyzed. 53 recipients received donation from donors after brain death （DBD group） and 28 from cardiac death （DCD group）. The deadline of follow-up is May 2016. Results During the period of observation, the mean follow-up was （17.26：t：10.85） months and patient＇s survival rate was 100%. When compared graft survival rate with the two groups, survival rate is 93.7% in DBD group and 92% in DCD group （~2 = 0.184,P = 0.668）. There was no statistically significant difference （P 〉 0.05）, the overall incidence of DGF was 28.4%. General DGF incidence is 28.4%, and DGF incidence between groups is X^2=4.402,P = 0.036. Infection rate within 1 year is X2 = 4.507,P = 0.034, and the difference is significant （P 〈 0.05）. There were no statistically significant difference （P 〉 0.05） in AR, eGFR of 1 month, proteinuria of 1 month after, transplantation and surgical complications. Conclusions Adult-to-adult single kidney transplantation from donation after cardiac death （DCD） has a higher rate of incidence of DGF, and the postoperative infection rate within 1 year. Renal transplantation from donation after cardiac death could have a good outcome.

关 键 词：脑死亡 心死亡 肾移植 临床疗效 

分 类 号：R699.2[医药卫生—泌尿科学]