分泌型卷曲相关蛋白5与2型糖尿病大血管病变的相关性及羟苯磺酸钙的干预性研究  

Relationship between Sfrp5 and T2DM macroangiopathy and activation of calcium dobesilate

作　　者：李兰芳[1] 曾姣娥[1] LI Lan- fang ZENG Jiao-e(Department of Endocrinology, Jingzhou Central Hospital, Jingzhou 434020, Chin)

机构地区：[1]湖北省荆州中心医院内分泌科,434020

出　　处：《实用医学杂志》2016年第18期3044-3046,共3页The Journal of Practical Medicine

基　　金：荆州市2015年医疗卫生科技计划项目(编号:2015039)

摘　　要：目的:探讨分泌型卷曲相关蛋白5(Sfrp5)与2型糖尿病(T2DM)大血管病变的相关性及羟苯磺酸钙的干预作用。方法:T2DM患者分为实验组(IMT≥0.90 mm)65例和对照组(IMT<0.90 mm)30例,前者随机分为A组(羟苯磺酸钙治疗)30例和B组(常规治疗)35例。20位健康人作为健康对照组。检测并比较治疗前后各组Sfrp5、IL-10、TC、TG、FPG、Hb A1c、IMT水平。结果:实验组、对照组Sfrp5、IL-10低于正常组(P<0.01),实验组低于对照组(P<0.05)。相关分析显示,Sfrp5、IL-10与各检测指标呈不同程度的负相关,Sfrp5与IL-10呈正相关(P<0.05)。A、B两组血糖、血脂、Hb A1c及IMT较治疗前下降,A组Sfrp5、IL-10升高(P<0.01),B组Sfrp5、IL-10较治疗前无统计学差异(P>0.05)。A组IMT下降幅度高于B组(P<0.05)。结论 :Sfrp5与大血管病变呈负相关,羟苯磺酸钙可升高Sfrp5、IL-10水平,延缓大血管病变的进展。Objective To investigate the relationship between Sfrp5 and T2DM macroangiopathy, and to evaluate the activation of calcium dobesilate. Methods T2DM patients were divided into experimental group （IMT≥0.90 mm,n = 65）and control group （IMT 〈 0.90 mm, n = 30）and patients in experimental group were randomly further divided into group A（n = 30,treated with calcium dobesilate） and group B（n = 35, treated with routine therapy）. Another 20 healthy control were involved as normal group. Sfrp5, IL-10, TC, TG, FPG, HbAlc and IMT were observed before and after treatment. Results Sfrp5 and IL-10 in experimental group and control group were lower than those in normal group （P 〈 0.01）and Sfrp5 and IL-10 in experimental group were lower than those in control group （P 〈 0.05）. Correlation analysis showed that sfrp5 and IL-10 were negatively correlated with these above-mentioned indicators and Sfrp5 was positively Correlated with IL-10（P 〈 0.05）. After 16-week treatment, the contents of FBG, lipid, HbAlc and IMT were decreased in group A and B, but Sfrp5 and IL-10 were increased in group A （P 〈 0.01）. Sfrp5 and IL-10 didn＇t alter significantly in group B （P 〉 0.05）. IMT in group A were decreased when compared with group B （P 〈 0.05）. Condnsion Sfrp5 is negatively correlated with macroangiopathy. Calcium dobesilate can elevate Sfrp5 and IL-10,thus delay the progression of macroangiopathy.

关 键 词：2型糖尿病大血管病变 分泌型卷曲相关蛋白5 白介素-10 羟苯磺酸钙 

分 类 号：R587.2[医药卫生—内分泌]