感染性休克患者血必净治疗前后LA与CRP及PCT变化研究  

Changes of LA,CRP and PCT before and after the Xuebijing treatment for patients with infectious shock

作　　者：刘玉香[1] 郑玉明[1] 张玉梅 王明英 张秀华 

机构地区：[1]滨州市人民医院急诊科 [2]随访中心,山东滨州256600 [3]滨州市沾化区人民医院护理部 [4]感染科,山东滨州256800

出　　处：《中华医院感染学杂志》2016年第20期4627-4628,4680,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(30772808)

摘　　要：目的通过探讨感染性休克患者血必净治疗前后LA、CRP、PCT及血流动力学的变化,观察血必净治疗感染性休克的临床疗效。方法选择2014年8月-2015年9月医院接收的感染性休克患者192例,分为观察组与对照组各96例,对照组患者以常规方法进行治疗,观察组患者在常规治疗基础上以血必净治疗,观察其临床效果。结果经治疗后,两组患者血流动力学指标变化均有一定程度改善,但观察组患者治疗后HR(75.5±9.6)次/min、CI(3.9±0.5)L/min/m2、CVP(80.5±4.6)mmHg以及MAP(77.4±2.7)mmHg与PAWP(14.8±1.1)mmHg改善情况明显优于对照组,差异有统计学意义(P<0.05);两组患者LA、CRP、PCT指标变化均有所降低,但观察组患者治疗后LA(1.5±0.6)mmol/L、CRP(14.4±3.2)mg/L、PCT(1.5±0.3)ng/L,降低程度大于对照组,差异有统计学意义(P<0.05);观察组患者死亡率为12.5%,明显低于对照组35.5%,差异有统计学意义(P<0.05);两组患者肺水肿发生率比较,差异无统计学意义。结论血必净治疗感染性休克患者效果较好,可使其血流动力学得到有效改善,并且能够对炎性反应进行有效抑制,促使其尽快康复。OBJECTIVE To study the changes of LA, CRP, PCT and haemodynamics before and after the Xuebijing treatment for patients with infectious shock and to observe the clinical effect of Xuebijing to infectious shock. METHODS A total of 192 cases of patients with septic shock from Aug. 2014 to Sep. 2015 in our hospital were selected, who were divided into observation group and the control group, 96 cases in each group. The patients were in the control group with conventional treatment, patients in the observation group on the basis of routine treat- ment and Xuebijing injection in the treatment, and the clinical effects were under observation. RESULTS After treatment, the changes of hemodynamics of two groups of patients were improved, but in the observation group after treatment HR （75.5±9.6） /rain, CI （3.9±0.5） L/min/m2 , CVP （80.5±4.6） mmHg and MAP （77.4± 2.7） mmHg and PAWP （14.8±1.1） mmHg were better significantly than those in the control group（P〈0.05）. After treatment, the two groups of patients with LA, CRP, PCT index changes were decreased, but the observa- tion group after treatment LA （1.5±0.6） mmol/L, CRP （14.4±3.2） mg/L, PCT （q. 5±0.3） ng/L were de- creased more than those in the control group, and the differences between the two groups were significant （P〈0. 05）. The death rate in observation group was 12.5%, which was lower than 35.5% in control group, and there was no significant difference. CONCLUSION Septic shock could get a better effect by Xuebijing treatment, which can effectively improve the hemodynamics of the patients, and can effectively inhibit the inflammatory response in patients to make the ＇rehabilitation as soon as possible.

关 键 词：感染性休克 血必净 血流动力学 炎性因子 

分 类 号：R631.4[医药卫生—外科学]