不同时间使用抗菌药物与脊椎术后感染临床相关性分析  

Clinical correlation analysis of different times of the use of antibiotics and infection after spine surgery

作　　者：王朝君[1] 冯艳红[1] 张晓丽[1] 杜淑娟[1] 王喜[1] 张双伟[1] 范金鹏[1] 徐凤周[1] 王韦江[1] 

机构地区：[1]石家庄市第一医院骨科,河北石家庄050011

出　　处：《中华医院感染学杂志》2016年第20期4672-4674,共3页Chinese Journal of Nosocomiology

基　　金：河北省医学科研重点课题(ZD20140277)

摘　　要：目的探讨不同时间使用抗菌药物与脊柱手术后感染之间的相关性,为临床预防脊柱手术后感染提供依据。方法选取医院2013年1月-2015年12月150例脊柱手术患者为研究对象,依据手术中抗菌药物的不同使用时间进行分组,A组70例患者于术前30min使用抗菌药物,术后不使用,B组80例患者术前不使用抗菌药物,术后持续用药3d,观察两组患者的术后感染率,抗菌药物使用时间、术后退热时间、住院时间及治疗费用。结果患者术后感染率A组为7.1%,B组为16.3%,两组数据比较差异有统计学意义(P<0.05);A组患者抗菌药物使用时间、术后退热时间、住院时间和治疗费用分别为(1.1±0.3)d、(1.3±0.4)d、(11.7±3.2)d、(2643.8±321.8)元,B组患者为(3.4±0.8)d、(2.7±0.6)d、(18.2±4.1)d、(3174.5±355.1)元,两组数据比较差异有统计学意义(P<0.05)。结论临床中脊柱手术围术期不同时间使用抗菌药物对术后感染具有一定的影响,术前30min用药可以较好的预防术后感染,并缩短患者的住院时间。OBJECTIVE To study the correlation between time of the use of antibiotics and infection after spine sur- gery, so as to provide evidences for clinic prevention of infection after spinal surgery. METHODS A total of 150 ca- ses of patients underwent spinal surgery in the hospital from Jan. 2013 to Dec. 2015 were selected as the objects of study, and were divided into two groups according to the different times of the use of antimicrobial agents in the surgery. Patients of group A （70 cases）, were given antibiotics half an hour before surgery and did not take anti- biotics after surgery, and patients of group B （80 cases） were given 3 days of antibiotics after surgery and without preoperative use of antibiotics. RESULTS A postoperative infection rate of group A and B were 7.1% and 16.3%, with significant difference （P〈0.05）. The usage time of antibiotics, postoperative fever clearance time, hospital- ized time and treatment costs of group A were （1.1±0.3） d, （1.3±0.4） d, （11.7±3.2） d, （2643.8±321.8） yuan, of group B were （3.4 ±0.8） d, （2.7±0.6） d, （18.2±4.1） d, （3174.5±355.1） yuan, and differences two sets of data were significant （P〈0.05）. CONCLUSION The perioperative use of antimicrobial drugs at differ- ent times during clinical spine surgery has some influence on the infection after surgery. Taking antimicrobial drugs half an hour before surgery can better prevent postoperative infections and shorten the length of hospital stay of patients.

关 键 词：抗菌药物 使用时间 脊柱手术 感染 相关性 

分 类 号：R978.1[医药卫生—药品]