传染性单核细胞增多症患儿血淋巴细胞亚群及NK细胞的变化分析  

Changes of peripheral blood lymphocyte subsets and NK cell of children with infectious mononucleosis

作　　者：陈春法[1] 张文喜[1] 赵佳佳[1] 高未 蔡奔奔 缪英英 

机构地区：[1]台州市第一人民医院儿科,浙江台州318020

出　　处：《中华医院感染学杂志》2016年第20期4727-4729,共3页Chinese Journal of Nosocomiology

基　　金：浙江省台州市科技局基金资助项目(1501KY38)

摘　　要：目的研究分析传染性单核细胞增多症患儿外周血淋巴细胞亚群及NK细胞的变化,为该病患儿的免疫调节提供理论依据。方法选择2010年4月-2015年11月医院收治56例传染性单核细胞增多症患儿为观察组,并以同时期体检56名健康儿童为对照组,检测两组儿童外周血淋巴细胞亚群及NK细胞,并分析其变化;比较观察组不同白细胞水平患儿的检测结果,同时采用logistic分析上述研究指标与传染性单核细胞增多症的关系。结果观察组患儿外周血CD_(19)^+、CD_(16)^+CD_(56)^+及CD_3^+CD_4^+、CD_4^+及CD_4^+/CD_8^+水平均低于对照组,而CD_8^+则高于对照组,差异有统计学意义(P<0.05);观察组患儿不同白细胞水平检测结果差异也有统计学意义(P<0.05);经logistic分析显示,外周血淋巴细胞亚群及NK细胞指标均与传染性单核细胞增多症有密切的关系,差异有统计学意义(P<0.05)。结论传染性单核细胞增多症患儿外周血淋巴细胞亚群及NK细胞的变化较大,应加强对传染性单核细胞增多症患儿的免疫调节干预。OBJECTIVE To observe and study the changes of peripheral blood lymphocyte subsets and NK cell of children with infectious mononucleosis,in order to provide evidence for the immunoregulation of children with the disease. METHODS A total of 56 children with infectious mononucleosis in hospital from Apr. 2014 to Nov. 2015 were selected as the observation group, and 56 healthy children at the same period were selected as the control group. The peripheral blood lymphocyte subsets and NK cell of children were detected and analyzed to understand- ing the changes. The detection results were compared between children with different white blood cell levels and the relationship between these data and infectious mononucleosis were studied by the logistic analysis. RESULTS The peripheral blood CD19 ＋ , CD16 ＋ CD56 ＋ and CD3 ＋ CD4 ＋ , CD4 ＋ and CD4 ＋/CD8 ＋ in observation group were all lower than control group, but CH5 ＋ higher than control group, and the difference was statistically significant （P 〈0.05） ; The detection results of observation group with different white blood cell levels had obvious differences （P〈0. 05） ,and those peripheral blood lymphocyte subsets and NK cell indexes all had close relationship to infec- tious mononucleosis by the Logistic analysis with statistically significant difference （P〈0.05）. CONCLUSION The change of peripheral blood lymphocyte subsets and NK cell of children with infectious mononucleosis are great,so the immunoregulation of children with infectious mononucleosis should be paid more attention.

关 键 词：传染性单核细胞增多症 外周血淋巴细胞亚群 NK细胞 

分 类 号：R446[医药卫生—诊断学]