学龄前反复呼吸道感染患儿微量元素与红细胞免疫的变化观察  

Observation of the changes of trace elements and erythrocyte immunity in the preschool children with recurrent respiratory tract infections

作　　者：屠苗英 王秀敏[2] 毛立英 周均华 陈巧萍 

机构地区：[1]诸暨市妇幼儿童医院儿科,浙江诸暨311800 [2]浙江大学附属儿童医院内分泌科,浙江杭州320058

出　　处：《中华医院感染学杂志》2016年第20期4741-4742,4791,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81370930)

摘　　要：目的探讨微量元素和红细胞免疫功能变化对学龄前反复呼吸道感染患儿临床诊治的意义,为反复呼吸道感染的相关研究提供参考借鉴。方法选取2010年12月-2013年12月收治的反复呼吸道感染患儿44例为研究组,同时选取同期体检的健康儿童44名为对照组,针对两组儿童的细胞免疫指标(CD_3^+、CD_4^+CD_(25)^+、CD_4^+)、红细胞免疫指标(ATER、FEER和DYER)和微量元素指标(Zn^+、Ca^+、和Cu^+)等水平进行观察和比较。结果研究组患儿CD_3^+、CD_4^+CD_(25)^+、CD_4^+指标水平分别为(56.54±4.56)%、(15.43±1.45)%和(35.45±4.32)%,低于对照组,差异有统计学意义(P<0.05);研究组患儿ATER、FEER和DYER指标水平分别为(49.34±4.35)%、(60.43±6.09)%和(29.34±3.24)%,低于对照组,差异有统计学意义(P<0.05);研究组患儿Zn^+和Ca^+指标水平分别为(33.87±4.30)μmol/L和(1.32±0.21)mmol/L,低于对照组,研究组患儿Cu^+水平为(15.32±2.19)mmol/L,高于对照组,差异有统计学意义(P<0.05)。结论反复呼吸道感染可导致儿童细胞免疫指标、红细胞免疫相关指标的降低和微量元素相关指标的异常,针对上述指标的监测有助于疾病的预防和诊治。OBJECTIVE To explore the clinical significance of the changes of trace elements and erythrocyte immune function for the diagnosis of preschool children with recurrent respiratory tract infections, so as to provide refer- ence for relevant research of recurrent respiratory tract infections. METHODS A total of 44 cases of children with recurrent respiratory tract infections from Dec. 2010 to Dec. 2013 were chosen as the study group, while 44 cases of healthy children at the same period had examination were as the control group. The immune index cell （CD3 ＋ , CD4 ＋ ,CD25 ＋ ,CD4 ＋ ）, red blood cell immunity index （ATER, FEER and DYER） and trace indicators （Zn＋, Ca＋ and Cu＋ ） and other levels were observed and compared. RESULTS The CD3 ＋ , CD4 ＋ , CD2.5 ＋ and CD4 ＋ index lev- els of the study group were （56.54 ± 4.56）%, （15.43 ± 1.45）% and （35.45 ± 4.32）%, significancely lower than the control group of （70.34 ±5.46）%, （23.45± 2.35） % and （47.35 ± 5.43） % （P〈0.05）. The index levels of Zn＋ and Ca＋ in study group were （33. 87±4.30）μmol/L and （1.32＋0.21）mmol/L, signifieancely lower than control group, and Cu＋ was （15.32±2.19）mmol/L, significancely higher than control group（P〈0.05）. CONCLUSION Recurrent respiratory tract infections can lead to the decreasing of immune parameters, erythrocyte immunity relative indexes, and the abnormal of trace element related indicators in the preschool children. There- fore the monitoring of these indicators can help to prevent and treatment of disease.

关 键 词：反复呼吸道感染 微量元素 红细胞免疫 

分 类 号：R725.6[医药卫生—儿科]