泰安地区ALDH2基因多态性与急性冠脉综合征易感性的关系  

Relationship between ALDH2 gene polymorphisms and acute coronary syndrome in Taian

作　　者：丛绍强[1] 韩文倩[1] 刘卫[2] 

机构地区：[1]泰安市中心医院药学部,山东泰安271000 [2]中国人民解放军第88医院药学部,山东泰安271000

出　　处：《中国医院药学杂志》2016年第19期1629-1633,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨乙醛脱氢酶2(ALDH2)基因多态性与急性冠脉综合征的相关性,为急性冠脉综合征患者的预防提供依据。方法:收集所有研究对象血液样本,包括健康体检者60例,入院确诊为急性冠脉综合征患者60例。血样采用PCR测序法进行基因多态性检测。对所有研究对象详细记录基本临床资料。所有数据分析运用SPSS 19.0统计软件进行处理。结果:泰安地区ALDH2基因型及等位基因G、A在急性冠脉综合征(ACS)组和正常组中分布具有显著性的统计学差异,ALDH2基因多态性可能是急性冠脉综合征发生的危险因素。经单因素Logistic回归分析结果提示ALDH2基因多态性、饮酒、高血压、糖尿病、既往急性心肌梗死病史以及性别与急性冠脉综合征发生的相关性,进一步经多因素Logistic回归分析结果显示年龄、饮酒、高血压、既往心肌梗死病史是急性冠脉综合征发生的独立危险因素。结论:泰安地区人口中急性冠脉综合征患者乙醛脱氢酶2基因多态性以及等位基因ALDH2*2的分布明显高于正常人群。年龄、饮酒、高血压、既往心肌梗死病史等成为影响急性冠脉综合征发生的危险因素。OBJECTIVE To investigate distribution of ALDH2 gene polymorphisms in Shandong Taian,and relationship between ALDH2 gene polymerphisms and acute coronary syndrome（ACS）,so as to provide a basis for prevention against acute coronary syndrome.METHODS Blood samples were collected from all subjects,including 60 acute coronary syndrome patients and 60 healthy people as control.Blood samples were used to detect genetic polymorphism by PCR-sequencing method.Following information was recorded for each patient：hospital number,age,gender,admission diagnosis,lipid levels（total cholesterol,HDL,LDL-C,triglycerides）,hypersensitive C-reactive protein,history of smoking and drinking,high blood pressure,diabetes,other medical history and family history of cardiovascular disease,history of MI and coronary arteriography.All data were processed with SPSS19.0statistical software.RESULTS Distribution of A,G alleles of ALDH2 genotypes in acute coronary syndrome group and control group had statistically significant differences as tested byχ2 test.ALDH2 polymorphism might be a risk factor in occurrence of acute coronary syndromes.Single factor logistic regression analysis results revealed that ALDH2 gene polymorphism,drinking,hypertension,diabetes,history of MI and gender were risk factors for coronary heart diseases.Multi-factor logistic regression analysis showed that age,drinking,hypertension,history of MI were independent risk factors for acute coronary syndrome.CONCLUSION ALDH2 gene polymorphism and distribution of allele A are obviously more in acute coronary syndrome patients than in normal people.Age,drinking,hypertension and history of MI are risk factors for acute coronary syndrome.

关 键 词：乙醛脱氢酶2 基因多态性 急性冠脉综合征 易感性 

分 类 号：R968[医药卫生—药理学]