动物基因组学重测序的应用研究进展  

The Research Progress and Application of Resequencing Based on Animal Genomics

作　　者：汪文强[1,2] 赵生国[2] 马利青[3] 郭继军 马月辉[1] 赵倩君[1] 

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]甘肃农业大学动物科学技术学院,兰州730070 [3]青海省畜牧兽医科学院,西宁810016 [4]青海省畜牧总站,西宁810001

出　　处：《畜牧兽医学报》2016年第10期1947-1953,共7页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：中国农业科学院科技创新工程(ASTIP-IAS01);国家自然科学基金项目(31201765);国家绒毛用羊产业技术体系(CARS-40-01)

摘　　要：随着第二代测序技术的研发和应用,基因组学的研究不断出新,为其带来了更新的科研方法和解决方案。基因组测序可以更深地了解一个物种的分子进化、基因组成和基因调控等特点,特别基因组重测序技术的发展和应用,将基因组学的研究推向了多领域、多样化、多功能的新阶段。现已从变异检测、性状定位、遗传图谱构建、群体进化分析等方面取得丰硕成果。文章阐述了动物基因组重测序学领域中全基因组测序技术和简化基因组测序技术的应用现状和发展趋势。With the application and development of the next generation sequencing technique,the researches of genomics are constantly updating,which finds out new solutions and technologies to genomics.The genome sequencing is competent to learn the population evolution,gene composition and gene regulation deeply,especially the application and development of genome resequencing technology,which makes the genome research come into being a new era in multiregion,diversification and multifunction.Nowadays the next generation sequencing technique has made a large progress in mutation detection,fine mapping of important genes,genetic map construction,analysis of population evolution,and so on.The review states application status and development tendency of whole genome sequencing technology and reduced-representation genome sequencing technology in animal genome resequencing.

关 键 词：重测序 群体进化 变异检测 性状定位 遗传图谱 

分 类 号：S813.3[农业科学—畜牧学]