RAC1与肺癌发生及临床治疗的研究进展  

Research advances in RAC1 and lung cancer

作　　者：邹婷[1,2] 刘昭前[1,2] 

机构地区：[1]中南大学湘雅医院临床药理研究所,湖南长沙410008 [2]中南大学临床药理研究所,遗传药理学湖南省重点实验室,湖南长沙410078

出　　处：《中国临床药理学与治疗学》2016年第9期1055-1060,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家高技术研究发展计划(863项目)(2012AA02A517);国家自然科学基金(81373490,81573508);湖南省自然科学基金(2015TP1043)

摘　　要：RAC1作为一种小分子G蛋白,是调控多种细胞活动和基因表达的信号分子开关。它参与调控细胞的多种生命活动,如吞噬作用,黏附,细胞运动,细胞增殖,轴突的形成等。RAC1在肿瘤的血管生成,侵袭和转移中扮演着重要的角色。关于RAC1的剪接体RAC1b与肺癌的相关性研究也越来越深入,无论是在人体的肺癌组织样本中进行外显子测序,还是在转基因小鼠中进行研究,都得出了同样的结论,RAC1的表达与肺癌的发生发展具有显著的相关性。近年来,有研究发现RAC1抑制剂可以改善肺癌患者对EGFR抑制剂吉非替尼产生的耐药性,以RAC1为靶点的肺癌临床治疗在不断地进行深入研究。RAC1 as a member of the Rho family of small guanosine triphosphatases（ GTPases）,are signal molecular switches of cellular events and gene expression. It is critical for plenty of cellular activities,such as phagocytosis,adhesion and motility,cell proliferation and axonal. RAC1 plays an important role in cancer angiogenesis,invasion and migration. RAC1 b,an isoform of the RAC1 GTPase is being investigated deeply. No matter performed whole-genome sequencing and transcriptome sequencing in lung tumor / normal pairs, or research in transgenic mice. The same conclusion is that the expression of RAC1 is associated with lung cancer development. In recent years, some investigations show that RAC1 inhibition can treat EGFR inhibitor gefitinib-resistance in lung cancer,target RAC1 for lung cancer therapy is being investigated deeply.

关 键 词：RAC1 肺癌 细胞增殖与凋亡 侵袭 转移 

分 类 号：R968[医药卫生—药理学]