中药联合高效抗反转录病毒疗法对艾滋病患者预后的影响  

Effects of Chinese Drugs Combined HAART on the Prognosis of AIDS Patients

作　　者：李钦[1,2] 王莉[2] 金玉才 段俊国[1] 

机构地区：[1]成都中医药大学临床医学院,成都610075 [2]云南省中医中药研究院艾滋病研究中心,昆明650223 [3]禄劝彝族苗族自治县中医院中医科,昆明651500

出　　处：《中国中西医结合杂志》2016年第10期1169-1174,共6页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金地区科学基金资助项目(No.81360583);云南省医疗卫生单位内设研究机构科研项目(No.2016NS338)

摘　　要：目的观察中药联合高效抗反转录病毒疗法(highly active antiretroviral therapy,HAART)对艾滋病(acquired immune deficiency syndrome,AIDS)患者预后的影响。方法将2012年10月—2014年10月云南省中医中药研究院防治艾滋病试点项目治疗基地的437例AIDS患者根据临床分期及治疗方法分为ⅡA期空白组(患者拒绝中西药治疗)、ⅡA期中药组(患者拒绝接受HAART治疗,仅采用扶正抗毒丸或康爱保生丸治疗)、ⅡB期西药组(只接受HAART治疗)、ⅡB期中西药结合组(根据辨证接受扶正抗毒丸+HAART或康爱保生丸+HAART治疗)、Ⅲ期西药组及Ⅲ期中西药结合组(治疗方法分别同ⅡB期西药组及ⅡB期中西药结合组)。疗程为24个月。分别在治疗12、24个月时,观察各组AIDS患者发病和死亡人数所占百分比。结果 (1)治疗12、24个月,各组ⅡA、ⅡB期患者所占百分比呈逐渐降低趋势,Ⅲ期(发病期)及死亡患者所占百分比呈逐渐升高趋势,但各组间比较,差异无统计学意义(P>0.05)。(2)ⅡA期患者:与ⅡA期空白组比较,中药组ⅡA期患者所占百分比升高,ⅡB期、Ⅲ期及死亡患者所占百分比降低,差异无统计学意义(P>0.05);(3)ⅡB期患者:与ⅡB期西药组比较,中西药结合组ⅡA、ⅡB期患者所占百分比均升高,但差异亦无统计学意义(P>0.05),Ⅲ期(发病期)死亡患者所占百分比则明显降低(P<0.05);(4)Ⅲ期(发病期)患者:与Ⅲ期西药组比较,中西药结合组ⅡA、ⅡB期患者所占百分比均升高,Ⅲ期(发病期)死亡患者所占百分比降低,差异无统计学意义(P>0.05)。结论无论是否接受治疗、接受何种治疗,AIDS患者发病和死亡人数所占百分比随着时间的推移均呈现逐渐升高的趋势。中西药结合(扶正抗毒丸+HAART疗法或康爱保生丸+HAART疗法)能显著降低ⅡB期死亡患者所占百分比。Objective To observe the effects of Chinese drugs（ CD） combined highly active antiretroviral therapy（ HAART） on the prognosis of acquired immune deficiency syndrome（ AIDS） patients. Methods From October 2012 to October 2014,437 AIDS patients in the treatment base of AIDS prevention and control pilot project,Yunnan Institute of Traditional Chinese Medicine and Materia Medica,were assigned to stage ⅡA blank group（ refusal to any Chinese medical treatment or Western medical treatment）,stage ⅡA CD group（ refusal to HAART,and treated by Fuzheng Kangdu Pill / Kang＇ai Baosheng Pill alone）,stage ⅡB Western medicine（ WM） group（ receiving HAART alone）,stageⅡB CD combined WM group（ receiving Fuzheng Kangdu Pill / Kang＇ai Baosheng Pill based on syndrome typing ＋ HAART）,stage Ⅲ WM group（ the same treatment as stage ⅡB WM group）,and stage Ⅲ CD combined WM group（ the same treatment as stageⅡB CD combined WM group）. The therapeutic course for all was 24 months.The mortality and morbidity of AIDS patients were observed. Results（ 1） The percentages of stage ⅡA patients and stage ⅡB patients were in a gradually decreasing tendency in each group,while the percentages of stage Ⅲ（ onset） patients and dead patients were in a gradually increasing tendency after 12-and 24-month treatment. However,there was no statistical difference among them（P〉0. 05）.（2） As for stage ⅡA patients,as compared with stage Ⅱ A blank group,stage ⅡA patients occupied a higher percentage,stageⅡB,stage Ⅲ（ onset）,and dead patients occupied a lower percentage inⅡA CD group,but with no statistical difference among them（P〉0. 05）.（ 3） As for stageⅡB patients,as compared with stage ⅡB WM groups,stage ⅡA and ⅡB patients occupied a higher percentage,but with no statistical difference（P〉0. 05）. But dead patients in stage Ⅲ（ onset） occupied an obviously lowered percentage in the CD combined WM group（P〈0. 05）.（ 4） As for stage Ⅲ pa

关 键 词：艾滋病 高效抗反录病毒疗法 中西医结合 预后 

分 类 号：R512.91[医药卫生—内科学]