高密度脂蛋白胆固醇、血清白蛋白及C反应蛋白对急性重症胰腺炎的诊断价值  

The diagnostic value of high density lipoprotein cholesterol,serum albumin and C reactive protein in patients with severe acute pancreatitis

作　　者：付艳娜[1] 张焕荣[2] 

机构地区：[1]天津市第五中心医院营养科,天津300450 [2]天津市第五中心医院病案室,天津300450

出　　处：《中国生化药物杂志》2016年第8期139-140,144,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨血清高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDL-C）、血清白蛋白（serum albumin,SA）及C反应蛋白（C-reactive protein,CRP）联合检测对急性重症胰腺炎的诊断价值。方法选取2012年1月~2015年1月天津市第五中心医院收治的180例急性胰腺炎患者,其中重症急性胰腺炎（severe acute pancreatitis,SAP）87例,轻症急性胰腺炎（mild acute pancreatitis,MAP）93例,同时选取同期健康体检者100例作为对照组。比较3组患者血清HDL-C、SA及CRP水平。结果 SAP组和MAP组的HDL-C、SA水平显著低于对照组（P〈0.05）,CRP水平显著高于对照组（P〈0.05）;SAP组HDL-C、SA水平显著低于MAP组,CRP水平显著高于MAP组（P〈0.05）。相比于HDL-C、SA,CRP的灵敏度（89.4%）、特异度（95.0%）及准确度（92.0%）明显较高（P〈0.05）,3项指标联合检测的灵敏度（93.6%）、特异度（95.0%）及准确度（94.3%）明显高于任一3项指标的检测结果,差异均有统计学意义（P〈0.05）。结论血清HDL-C、SA及CRP联合检测能有效提高SAP的早期诊断率,为临床诊断提供参考依据。Objective To investigate the diagnostic value of serum high density lipoprotein cholesterol（ HDL-C）,serum albumin（ SA） and C reactive protein（ CRP） levels combined detection of severe acute pancreatitis. Methods 180 cases of acute pancreatitis were selected from January 2012 to January 2015 in Tianjin fifth central hospital,including 87 severe acute pancreatitis（ SAP） and 93 mild acute pancreatitis（ MAP）,and 100 cases of healthy people were selected as control group. The serum levels of HDL-C,SA and CRP were compared among three groups. Results HDL-C and SA in SAP group and MAP group were significantly lower than control group（ p〈0. 05）,the level of CRP was significantly higher than that of control group（ p〈0. 05）; HDL-C,SA levels in SAP group were significantly lower than those of MAP group,the CRP level was significantly higher than that of MAP group（ p〈0. 05）. Compared to HDL-C and SA,the sensitivity（ 89. 4%）,specificity（ 95%） and accuracy（ 92%） of CRP were significantly higher（ p〈0. 05）. The sensitivity（ 93. 6%） and specificity（ 95%） and accuracy（ 94. 3%） of combined detection of three markers were significantly higher than the detection results of the three indexes either,the differences were statistically significant（ p〈0. 05）. Conclusion The combined detection of serum HDL-C,SA and CRP levels can effectively improve the early diagnosis rate of SAP,and provide reference for clinical diagnosis.

关 键 词：高密度脂蛋白胆固醇 血清白蛋白 C反应蛋白 急性重症胰腺炎 

分 类 号：R446[医药卫生—诊断学]