依达拉奉联合纳洛酮治疗颅脑损伤对凝血功能异常的预后价值初探  

Exploration on prognostic value of edavarone combined with naloxone in treating coagulant function abnormality in craniocerebral injury

作　　者：谢彬[1] 王洪正[1] 

机构地区：[1]广东省深圳市罗湖区人民医院神经外科,广东深圳518000

出　　处：《中国生化药物杂志》2016年第7期106-108,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探索依达拉奉联合纳洛酮治疗颅脑损伤对凝血功能异常的预后价值。方法选择2014年3月-2016年3月广东省深圳市罗湖区人民医院神经外科收治的82例颅脑损伤患者,将患者编号录入计算机随机系统进行分组,观察组41例,采用依达拉奉联合纳洛酮治疗,对照组41例,采用常规治疗,对比2组氧化指标、凝血指标、脑水肿程度及昏迷评分。结果治疗2 w后,观察组凝血功能指标血小板计数（platelet count,PLT）、凝血酶原时间（prothrombin time,PT）、活化部分凝血酶时间（activated partial thrombin time,APTT）、凝血酶时间（thrombin time,TT）、纤维蛋白原（fibrinogen,Fg）、D二聚体（D dimer,DD）恢复优于对照组（P〈0.05）;观察组氧化物丙二醛（malondialdehyde,MDA）、超氧化物歧化酶（superoxide dismutase,SOD）水平指标改善较对照组显著（P〈0.05）,且观察组格拉斯哥昏迷评分（Glasgow coma scale,GCS）评分高于对照组（P〈0.05）。结论依达拉奉联合纳洛酮治疗颅脑损伤可有效降低氧化程度,恢复患者意识,纠正凝血功能异常。Objective To explore the prognostic value of edavarone combined with naloxone in treating coagulant function abnormality in patients with craniocerebral injury. Methods 82 patients with craniocerebral injury were selected from March 2014 to March 2016 in our hospital,and input computer after numbered. The observation group of 41 cases received edavarone combined with naloxone and control group of 41 cases received conventional treatment. The oxidative indexes,coagulation indicator,brain edema and GCS were compared between two groups. Results Two weeks after treatment,compared with control group,the platelet count（PLT）,prothrombin time（PT）,activated partial thrombin time（APTT）,thrombin time（TT）,fibrinogen（Fg）,D dimer（DD） in observation group improved better（P〈0. 05）; the levels of malondialdehyde（MDA）,superoxide dismutase（SOD） in observation group improved better（P〈0. 05）,and the Glasgow coma scale（GCS） in observation group was higher（P〈0. 05）. Conclusion Edavarone combined with naloxone could effectively reduce the degree of oxidation,restore patients＇ consciousness and correct coagulant function abnormality in the treatment of patients with craniocerebral injury.

关 键 词：依达拉奉 纳洛酮 颅脑损伤 凝血功能异常 

分 类 号：R651.15[医药卫生—外科学]