斑蝥酸钠维生素B_6在鼻咽癌放化疗患者中的临床应用价值  

Clinical application value of disodium cantharidinate and vitamin B_6 chemotherapy in nasopharyngeal carcinoma

作　　者：应晓珍[1] 许亚萍[2] 吴鹤[1] 林霞[3] 鲍黎明[1] 

机构地区：[1]温州医科大学附属第五医院丽水市中心医院放疗科,浙江丽水323000 [2]温州医科大学浙江省肿瘤医院放疗科,浙江温州310000 [3]丽水市中心医院胸外科,浙江丽水323000

出　　处：《中国生化药物杂志》2016年第7期141-144,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨斑蝥酸钠维生素B6联合同步放化疗对鼻咽癌患者的临床治疗效果。方法选取2013年1月-2015年10月温州医科大学附属第五医院（丽水市中心医院）放疗科进行同步放化疗治疗的94例晚期局部鼻咽癌患者,根据患者是否应用斑蝥酸钠维生素B6分为观察组和对照组各47例,对比2组放化疗近期疗效及实验室指标。结果观察组和对照组的同步放化疗缓解率、总有效率差异无统计学意义。治疗前,2组患者的外周血白细胞（WBC）、红细胞（RBC）、血红蛋白（Hb）、血小板（PLT）、谷胱甘肽过氧化物酶（GSH-PX）、超氧化物歧化酶（SOD）测定值差异无统计学意义;治疗2、4 w时,观察组外周血WBC、RBC、Hb、PLT、GSHPX、SOD测定值均显著高于对照组（P〈0.05）;观察组口腔黏膜炎发生率72.34%显著低于对照组的93.62%（P〈0.05）。结论斑蝥酸钠维生素B6联合同步放化疗对鼻咽癌患者的放化疗效果影响不明显,但是可以有效减轻放化疗引起的血象变化及不良反应。Objective To study the clinical efficacy of disodium cantharidinate and vitamin B6 combined with radiotherapy and chemotherapy in patients with nasopharyngeal carcinoma. Methods From January 2013 to October 2015 in department of radiotherapy of Lishui Central Hospital were selected for synchronous radiotherapy and chemotherapy in the treatment of 94 patients with locally advanced nasopharyngeal carcinoma patients,according to whether the patient application of disodium cantharidinate and vitamin B6 injection into observation group and control group,each group of47 cases. The chemotherapy and laboratory indexes were compared between two groups. Results There was no significant difference in total efficiency and remission rate of synchronous radiotherapy and chemotherapy between observation group and control group; before treatment,there was no significant difference in white blood cell（WBC）,red blood cell（RBC）,hemoglobin（Hb）,blood platelet（PLT）,glutathione peroxidase（GSH-Px）,superoxide dismutase（SOD） levels of peripheral blood between two groups; after 2 and 4 weeks of treatment,the WBC,RBC,Hb,PLT,GSH-Px,SOD levels in observation group were higher than those in control group（P〈0. 05）; oral mucositis incidence rate of observation group was 72. 34%,which was significantly lower than that of the control group of 93. 62%（P〈0. 05）. Conclusion The efficacy of disodium cantharidinate and vitamin B6 injection combined with radiotherapy and chemotherapy for nasopharyngeal carcinoma patients is not obvious,but could effectively reduce adverse reaction of chemotherapy induced changes in blood.

关 键 词：斑蝥酸钠维生素B6 同步放化疗 鼻咽癌 

分 类 号：R739.6[医药卫生—肿瘤]