“祛风止动方”治疗儿童抽动障碍的方-证-效研究  

Research on decoction-syndrome-effect of Qufeng Zhidong Decoction in treatment of tic disorder children

作　　者：倪建俐[1] 周亚兵[1] 张欣[1] 吴敏[1] 

机构地区：[1]上海交通大学医学院附属新华医院中医科,中国上海200092

出　　处：《教育生物学杂志》2016年第3期122-125,共4页Journal of Bio-education

基　　金：上海市卫生和计划生育委员会课题(2012L060A)

摘　　要：目的评价祛风止动方合舒郁、健脾、滋阴药治疗抽动障碍"一主证三兼证"的临床疗效,探讨方-证-效的相关性。方法将入选患儿随机分为方证对应组(65例)和方证不对应组(66例)。方证对应组为肝肺并调兼舒郁、健脾、滋阴三兼证;方证不对应组针对抽动障碍的核心证候,采用肝肺并调基本治则。两组分别于第4、8、12、24周进行中医症状、体征、疗效评价。结果方证对应组与方证不对应组总有效率分别为98%和90%,差异无统计学意义(P>0.05)。结论祛风止动方能显著改善抽动障碍患儿抽动症状及体征,且无不良反应。方证对应组总有效率略高于方证不对应组,但差异无统计学意义。Objective To evaluate the efficacy of Qufeng Zhidong Decoction with drugs for relieving the depressed liver, invigorating spleen, and nourishing Yin in the treatment of tic disorder which has a master syndrome and three accompanying syndromes,in order to discuss the correlation of decoction-syndrome-effect. Methods Patients were randomly divided into treatment group （65 cases） and the corresponding treatment group （66 cases） . The patients in the treatment group were divided into syndromes of regulating lung and liver with relieving the depressed liver, invigorating spleen and nourishing Yin. The patients in the corresponding treatment group were treated according to the core syndrome by regulating the function of the liver and the lung. The Chinese medicine symptoms, signs, and curative effect were evaluated in the tow groups in 4 ,8,12,and 24 weeks. Results The total effective rates of the treatment group and the corresponding treatment group were 98% and 90% , respectively, and the difference was not statistically significant （P 〉 0. 05 ） . Conclusion Qufeng Zhidong Decoction can significantly improve the symptoms and signs of tic disorder and has no toxic side effect. The total effective rate of the treatment group is slightly higher than the corresponding treatment group, but no significant differences were observed.

关 键 词：抽动障碍 祛风止动方 方-证-效研究 

分 类 号：R277.7[医药卫生—中医学]