B族维生素与糖尿病肾病的研究进展  

Research progress of B vitamins and diabetic nephropathy

作　　者：陈焕珍[1] 田冬梅[1] 

机构地区：[1]上海市普陀区人民医院内分泌科,200060

出　　处：《中国综合临床》2016年第9期855-858,共4页Clinical Medicine of China

基　　金：上海市普陀区人民医院院级科研项目（RYK15-10）

摘　　要：糖尿病肾病（ DN）是糖尿病微血管病变的主要表现之一，是糖尿病致残致死的一个主要因素。目前DN的治疗主要集中于治疗高血糖和高血压。尽管血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体拮抗剂能够延缓DN的进展，但是还有很多患者发展为肾衰竭。补充B族维生素在预防糖尿病微血管病变中的作用是近些年的研究热点。我们主要对B族维生素在糖尿病、DN发病过程中的作用及B族维生素补充治疗效果进行综述。Diabetic nephropathy（ DN） is one of the main manifestations of diabetic microvascular dis？ease,and it is a major factor in the death of diabetes.At present,the treatment of DN is mainly focused on the control of high blood sugar and high blood pressure.Although angiotensin converting enzyme inhibitors and angio？tensin II receptor antagonists can slow the progression of DN,there were a lot of patients deteriorate to renal fail？ure.The role of vitamin B supplementation in preventing microvascular complications of diabetes has already been a focus of research for some years.In this paper,the role of B vitamins in the pathogenesis of diabetes mellitus and DN,effect of vitamin B supplementation on treatment in DN were discussed.

关 键 词：糖尿病肾病 B族维生素 糖基化代谢终产物 

分 类 号：R587.2[医药卫生—内分泌]