固肾排毒液结肠透析对慢性肾衰竭患者微炎症状态的影响  

Influence of Colonic Dialysis with Gushen Paidu Liqiud(固肾排毒液) on Microinflammatory State of Chronic Renal Failure Patients at 1~3 Stage

作　　者：李桂霞[2] 许筠[2] 苏建平[2] 翟晓丽[2] 张茹[2] 胡晓文[1] 俞徽 

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]兰州市第二人民医院,甘肃省中医肾病医疗中心,甘肃兰州730046

出　　处：《中国中医药科技》2016年第5期512-515,共4页Chinese Journal of Traditional Medical Science and Technology

基　　金：甘肃省兰州市卫生科技发展项目(LZWSKY2014-1-04)

摘　　要：目的：探讨中药固肾排毒液结肠透析对慢性肾衰竭1~3期患者微炎症状态的影响。方法：将慢性肾衰竭1~3期患者72例随机分为常规治疗组32例（常规治疗）、中药结肠透析治疗组40例（在常规治疗组的基础上加用中药固肾排毒液结肠透析）,2 W为1个疗程,连续观察2个疗程。评价临床疗效并观察治疗前后2组患者血清hs-CRP、IL-6、TNF-α、Hcy水平的变化。同时取健康对照组30例,比较其与肾衰竭患者血清hs-CRP、IL-6、TNF-α、Hcy水平的差异。结果：常规组临床治疗显效率为21.88%,总有效率为81.25%;固肾排毒液结肠透析组显效率为25.00%,总有效率为87.50%;结肠透析治疗组较常规治疗组疗效显著,2组比较差异有统计学意义（P〈0.05）。肾衰竭患者血清hs-CRP、TNF-α、IL-6、Hcy水平均高于健康对照组,差异有统计学意义（P〈0.05）;中药固肾排毒液结肠透析治疗组治疗后血清hs-CRP、TNF-α、IL-6、Hcy水平均低于治疗前,常规治疗组治疗后的hs-CRP、IL-6、TNF-α水平均低于治疗前,差异均有统计学意义（P〈0.05）;Hcy水平变化无统计学意义（P〉0.05）。中药结肠透析治疗组降低hs-CRP、IL-6、TNF-α水平的作用较常规治疗组更明显,差异显著（P〈0.05）。结论：慢性肾衰竭1~3期患者存在微炎症反应,中药固肾排毒液结肠透析可改善氧化应激状态,从而改善微炎症状态。Objective： To investigate the influence of colonic dialysis with Chinese drugs Gushen Paidu Liqiud on microinflammatory state of chronic renal failure patients at 1 ~ 3 stage. Methods： 72 Cases of chronic renal failure patients at 1 ~ 3 stage were randomly divided into two groups,32 cases of standard treatment group with conventional treatment,40 cases of colonic dialysis with Chinese drugs treatment group which therapy based on standard treatment group combined with colonic dialysis with Chinese drugs,2 weeks was one treatment course,the treatment was lasted for 2 courses,serum hs- CRP,IL- 6,TNF- α,Hcy levels of the two groups before and after treatment were determined and 30 healthy persons were taken as the healthy control group. Results ： The obviously effective rate of standard treatment group was 21. 88% and the total effective rate was81. 25%; that in the colonic dialysis with Chinese drugs group was 25. 00% and 87. 50% respectively; the curative effect of the colonic dialysis with Chinese drugs group was better than that of control group,there was significant difference in the total effective rate between the two groups（ P〈0. 05）. The levels of serum hs- CRP,IL-6,TNF- α,Hcy in renal failure patients were all higher than those in healthy group with statistical difference（ P〈0. 05）. The hs- CRP,IL- 6,TNF- α,Hcy in colonic dialysis with Chinese drugs group were much lower to compare with before treatment（ P〈0. 05）; except Hcy,the serum hs- CRP,IL- 6,TNF- α in standard treatment group were lowered significantly to compare with before treatment（ P〈0. 05）,Hcy in standard treatmentgroup wasn ＇t statistical difference before and after treatment（ P〈0. 05）,the hs- CRP,IL- 6,TNF- αlevels in colonic dialysis with Chinese drugs treatmentgroup were significantly lower than those of the standard treatment group,with statistical difference（ P〈0. 05）.Conclusion： Microinflammation exist in chronic renal failure patients,colonic dialysis with Chinese drugs Gushen Paidu Liqi

关 键 词：肾功能衰竭 慢性 @固肾排毒液 结肠 透析 @微炎症 人类 

分 类 号：R285.6[医药卫生—中药学]