血清VEGF水平与类风湿性关节患者炎症指标的相关性  

Correlation between Serum VEGF Levels and Inflammatory Factors in Patients with Rheumatoid Arthritis

作　　者：高金芳[1,2] 陈晋[3] 施丹[4] 张莉[2] 郁淼[2] 

机构地区：[1]同济大学医学院,上海200092 [2]上海交通大学医学院附属新华医院崇明分院检验科,上海202150 [3]同济大学附属上海市肺科医院检验科,上海200433 [4]上海交通大学医学院附属新华医院崇明分院血液内科,上海202150

出　　处：《现代生物医学进展》2016年第29期5648-5650,共3页Progress in Modern Biomedicine

摘　　要：目的:研究类风湿性关节炎(RA)患者血清血管内皮生长因子(VEGF)与炎症指标的相关性。方法:随机选取2014年1月至2015年12月我院收治RA患者59例,包括32例RA活动期患者(RA活动期组)与27例RA缓解期患者(RA缓解期组),另抽取同期30例健康体检者作为对照组。应用双抗体夹心酶联免疫吸附法检测三组血清VEGF水平及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α),用免疫比浊法检测C-反应蛋白(CRP)水平,并采用Pearson相关分析RA患者血清VEGF水平与三项炎性因子之间的相关性。结果:三组血清VEGF以及CRP、IL-6、TNF-α整体比较,差异均有统计学意义(均P<0.05),且以上各指标在RA活动期组、RA缓解期组、对照组中依次降低,两两比较差异均有统计学意义(均P<0.05)。RA患者的血清VEGF与CRP、IL-6、TNF-α水平均呈正相关关系(r=0.556、r=0.517、0.682,均P<0.05)。结论:血清VEGF及CRP、IL-6、TNF-α在RA患者病理改变过程中均表达过度,且VEGF与炎性因子间存在协同相关作用。Objective： To explore the correlation between serum vascular endothelial growth factor （VEGF）and inflammatory fac- tors in patients with rheumatoid arthritis（RA）. Methods： 59 patients with RA treated in our hospital from January 2014 to December 2015 were selected,including 32 RA active patients （RA active group）and 27 RA remission patients （RA remission group）, and selected 30 healthy physical examination people as the control group in the same period. The serum VEGF, interleukin-6 （IL-6）, tumor necrosis fac- tor-α （TNF-α）were detected with double antibody sandwich enzyme-linked immunosorbent assay method in three groups, and the C-re- active protein （CRP）was detected with immunoturbidimetric assay method in three groups. The correlation between serum VEGF and those three inflammatory factors in patients with RA were analyzed with Pearson. Results： Serum VEGF, CRP, IL-6 and TNF-α in three groups were statistically different （P〈0.05）, which in RA active group, RA remission group and control group were reduced in turn, and the pairwise comparison were statistically different （P〈0.05）. Serum VEGF were positively correlated with CRP, IL-6, TNF-α in patients with RA respectively （r=0.556,0.517, 0.682, P〈0.05）. Conclusion： Serum VEGF and CRP, IL-6, TNF-α were all over expressed in pa- tients with RA during the pathological changes, and there is a synergistic effect between VEGF and inflammatory factors.

关 键 词：类风湿性关节炎 炎症因子 血管内皮生长因子 

分 类 号：R593.22[医药卫生—内科学]