强化阿托伐他汀治疗对ACS患者血脂水平的短期影响  

The Acute Effect of Intensive Atorvastatin Therapy on Lipid Profile in Patients with Acute Coronary Syndrome

作　　者：刘丹丹[1] 孙晓薇[1] 李亚平[1] 张莹莹[1] 李丽丽[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医院心内科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2016年第29期5773-5775,共3页Progress in Modern Biomedicine

基　　金：中国博士后基金项目(20100471008.2010);黑龙江省卫计委课题(2014-439)

摘　　要：目的:观察强化阿托伐他汀治疗对急性冠脉综合征(ACS)患者血脂水平的短期影响。方法:收集100例ACS患者,入院当天(the day of admission,D0)、入院第一天(the first day,D1)及入院第二天(The Second Day,D2)分别给予阿托伐他汀80mg治疗,入院D0立即采血化验血脂参数包括总胆固醇(total cholesterol,TC)、低度脂蛋白(LDL-cholesterol,LDL-C)、高密度脂蛋白(HDL-cholesterol,HDL-C)、甘油三酯(triglycerides,TG),分别在D1和D2晨起空腹复查。结果:总胆固醇的平均基线水平为5.24±0.07(D0),低密度脂蛋白为3.26±0.07,高密度脂蛋白胆固醇为1.07±0.07,甘油三酯为1.31±0.07。口服阿托伐他汀80毫克后第一天早晨,TC水平下降6.1%(D1)(与D0相比P<0.001),第二日下降13.2%(D2)(与D0相比P<0.001),LDL-C下降5.8%(D1)(DO与D1相比,P<0.001)和15.6%(D2)(DO与D2相比,P<0.001);HDL-C下降7.5%(D1)(DO与D1相比,P<0.001)和12.1(D2)(DO与D2相比,P<0.001);相反TG水平升高20.6%(D1)(DO与D1相比,P<0.001)和25.5%(D2)(DO与D2相比,P<0.001)。结论:强化他汀治疗对ACS患者血脂短期的影响与长期的影响是不同的,TC,LDL和HDL在短期内是下降的,而TG是升高的。Objective： To investigate the acute effect on serum total cholesterol（TC）, high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol （LDL-C）and triglycerides （TG）of intensive atorvastatin therapy in patients with ACS. Methods： We have analyzed a group of 100 patients with ACS （mean age 62.1）, Atorvastatin 80 mg was administered at admission and then once daily for the rest of hospitalization. The levels ofTC, LDL, HDL and TG were measured at admission（D0）, and then every morning of hospital- ization （D1,D2）. Results： The mean entry values （DO） ofTC, LDL, HDL and TG were 5.25, 3.27, 1.08 and 1.30 （mmol/L）, respectively. The therapy with atorvastatin 80 mg resulted in a decrease of TC levels in the D1 by 6.4% and in the D2 by 13.5%（P〈0.001 for all com- parisons with the entry value DO）; LDL was decreased by 6.4%（D1）and 16.2% （D2）（P〈0.001 vs DO）; the level of HDL was decreased by 9.2%（D1）and 13.9%（D2）（P〈0.001 vs DO）. In contrast, the TG level was higher in the D1 by 22.3% and in the D2 by 26.9%（P〈0.05 vs. DO）. Conclusions： The intensive statin therapy started at admission in ACS patients have a highly significant imediate effect on lipid pa- rameters.TC and LDL levels were reduced, increase in TG and reduction in HDL levels suggest a different acute effect of intensive statin on lipid levels compared with long-term treatment of ACS patients.

关 键 词：急性冠脉综合征 阿托伐他汀 血脂 

分 类 号：R541.4[医药卫生—心血管疾病]