品行障碍青少年疼痛共情异常的脑激活特征  

Abnormal Brain Activation of Empathy for Pain in Conduct Disorder Adolescents

作　　者：孙小强[1] 于伟霞[1] 袁术文[2] 高一点 姚树桥[1] 

机构地区：[1]中南大学湘雅二医院医学心理中心,长沙410011 [2]中南大学湘雅二医院放射科,长沙410011

出　　处：《中国临床心理学杂志》2016年第5期771-774,818,共5页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金(项目编号:81471384)

摘　　要：目的:利用功能磁共振技术,探讨品行障碍(Conduct disorder,CD)青少年和健康对照组(Healthy control,HC)在共情任务下大脑活动的差异。方法:通过磁共振扫描疼痛共情任务时被试的大脑活动,分析其在共情任务时大脑活动特点;提取感兴趣脑区的激活信号,分别与共情、冲动、攻击、冷漠无情特质的行为学指标做相关分析。结果:CD青少年冲动、攻击、冷漠无情特质得分显著高于HC组。观看疼痛视频时,CD组右侧岛叶、顶下小叶和左侧前扣带回的激活水平明显高于HC组。右侧岛叶、顶下小叶和左侧前扣带回的激活水平和两组青少年的攻击性、冲动性、冷漠无情特质得分存在正相关。结论:右侧岛叶、顶下小叶和左侧前扣带回的过度激活可能是CD青少年疼痛共情能力缺陷的神经机制。Objective： To examine the activation levels in conduct disorder（CD） adolescents and healthy controls（HC） adolescents using an empathy task with functional magnetic resonance imaging（fMRI）. Methods： Subject was scanned by fMRI while performing an empathy task, then the brain activation were analyzed; some brain regions were selected as the re- gion of interest（ROI）, then the relationships between them and scales scores of empathy, aggression, impulsivity, callous-un- emotional traits were investigated. Results： The scales scores of aggression, impulsivity, callous-unemotional traits of CD subjects were significantly higher than HC subjects. The right insula（rAI）, the right inferior partial lobule（rIPL） and the left anterior cingulate gyrus（1ACC） showed greater responses in CD subjects than in HC subjects when watching painful videos. There was a positive correlation of all the subjects with the higher scores of aggression, impulsion and callous traits tending to have greater responses in the rAI, 1ACC and rIPL（P〈0.05）. Conclusion： The overactivation of the rAI, rIPL and 1ACC could explain deficits of empathy for pain in adolescents with CD in neural mechanism.

关 键 词：品行障碍 共情 功能性磁共振 

分 类 号：R395.1[哲学宗教—心理学]