基于细胞凋亡探讨针刺作用机理的研究述评  

Research Review of the Action Mechanism of Acupuncture Based on Cell Apoptosis

作　　者：陈琳[1] 吴巧凤[1] 杨明晓[1] 邓淑芳[1] 柏琳[1] 陈亮[1] 梁繁荣[1] CHEN Lin WU Qiao-feng YANG Ming-xiao DENG Shu-fang BAI Lin CHEN Liang LIANG Fan-rong(School of Acupuncture and Tuina,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学针灸推拿学院,成都610075

出　　处：《上海针灸杂志》2016年第10期1143-1146,共4页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家重点基础研究发展计划(2012CB518501);教育部霍英东基础研究基金(141041);四川省科技厅项目(2015JQO058)

摘　　要：细胞凋亡是指由基因控制的细胞自主有序的死亡过程,它们在促进生物体的进化、调控多个系统的发育以及维持内环境的稳定中起着重要的作用。其中线粒体通路、死亡受体通路和内质网通路是细胞凋亡的主要通路。随着针刺基础科研的迅猛发展,各项成果显示针刺发挥疗效的重要机制之一与细胞凋亡密切相关。目前发现与针刺凋亡作用相关的凋亡分子研究主要集中在P53、Bcl-2家族、Cyt-C、Caspase、死亡受体Fas/Fasl和TNFR1/TNF-?、FADD-Caspase8、PERK等,通过对这些凋亡分子或基因产生影响,针刺发挥了改善组织缺血状态、保护神经细胞、减轻炎症、改善内分泌紊乱等众多作用。该文对与针刺作用密切相关的细胞凋亡途径及重要分子进行了总结与述评,为今后的相关研究提供一些有益参考。Apoptosis refers to the programmed death process of cells modulated by genes.It plays an important role in promoting the evolution of organisms,regulating the development of multiple systems,and maintaining the stability of internal environment.The major apoptosis pathways include mitochondrial pathways,death receptor pathways,and endoplasmic reticulum pathways.With the rapid development of the scientific research on acupuncture,it＇s revealed that cell apoptosis should be closely related to the action of acupuncture.So far,the major apoptosis factors involved in relevant researches are P53,Bcl-2 family,Cyt-C,Caspase,Fas/Fasl,TNFR1/TNF-？,and FADD-Caspase8,and PERK,etc.Via influencing these apoptosis factors or genes,acupuncture can produce various effects in improving tissue ischemia,protecting neural cells,reducing inflammation,and correcting endocrine disorders.This article summarized and reviewed the apoptosis pathways and key factors related to the action of acupuncture,to provide some beneficial references for future studies.

关 键 词：针刺 细胞凋亡 作用机理 综述文献 

分 类 号：R2-03[医药卫生—中医学]