心率变异性与高血压病动脉硬化和早期肾脏损害的相关性研究  

Correlation of heart rate variability with arteriosclerosis and early kidney impairment in hypertension

作　　者：周辉[1] 王雅琴[2] 刘迎新[2] 朱小玲[2] 陈志恒[2] 

机构地区：[1]中南大学湘雅公共卫生学院,湖南长沙410078 [2]中南大学湘雅三医院健康管理中心

出　　处：《实用预防医学》2016年第11期1281-1283,共3页Practical Preventive Medicine

基　　金："十二五"国家科技支撑计划(2013BAI04B01)

摘　　要：目的探讨心率变异性与高血压病动脉硬化和早期肾损害的相关性。方法对健康体检中筛选已确诊原发性高血压病164例,进行心率变异性(HRV-SDNN)、尿微量白蛋白和臂踝脉搏波传导速度(ba PWV)以及血压、BMI和血生化检查检测,并与200例健康受试者(正常对照组)进行对比分析。结果 (1)两组在脉压差、体重指数(BMI)、低密度胆固醇(LDL)、甘油三酯(TG)、高密度脂蛋白(HDL)、血糖、血尿酸、尿微量白蛋白、ba PWV和SDNN方面的比较,差异有统计学意义(均P<0.05)。(2)SDNN与ba PWV两者具有明显相关性(r=-0.72,P<0.01)。(3)SDNN与尿微量白蛋白两者具有显著相关性(r=-0.81,P<0.01)。结论心率变异性降低是高血压病动脉粥样硬化和早期肾功能损害的危险因素。通过心率变异性的分析,对评估和预测血管病变和靶器官损害均有重要的指导意义。Objective To explore the relationship of heart rate variability with arteriosclerosis and early kidney impairment in hypertension. Methods One hundred and sixty-four patients diagnosed with primary hypertension during physical examinations served as the hypertension group, and 200 healthy adults were considered as the normal control group. The heart rate variability （HRV）, urinary albumin, brachial-ankle pulse wave velocity （baPWV）, blood pressure, budy mass index （BMI） and blood biochemical indicators were detected and compared between the two groups. Results There were statistically significant differences in pulse pressure, BMI, LDL, TG, HDL, GLU, UA, urinary albumin, baPWV and standard deviation of normal-to-normal intervals （SDNN） between the hypertension group and the normal control group （all P〈0.05）. There was a significant correlation between SDNN and baPWV （r=-0.72, P〈0.01） as well as between SDNN and urinary albumin （r=-0.81, P〈0.01）. Conclusions The reduction of HRV is the risk factor for arteriosclerosis and early kidney impairment in hypertension. HRV assessment is of great value in evaluation and forecast of vascular lesion and target organ damage.

关 键 词：心率变异性分析 高血压病 动脉硬化 早期肾脏损害 

分 类 号：R69[医药卫生—泌尿科学]