Pickering乳液在药剂学的应用研究进展  

The Application Research Progress of Pickering Emulsion in Pharmaceutical Field

作　　者：张焦[1] 刘川 王帆[1] 易涛[3] 张继芬[1] 

机构地区：[1]西南大学药学院,重庆400716 [2]广安市食品药品检验检测中心,四川广安638500 [3]澳门理工学院高等卫生学校,澳门00853

出　　处：《中国药学杂志》2016年第20期1730-1734,共5页Chinese Pharmaceutical Journal

基　　金：西南大学基本科研业务费专项资助项目(XDJK2014C089);澳门理工学院资助研究项目(RP/ESS-06/2014)

摘　　要：Pickering乳液是用固体微粒取代表面活性剂做乳化剂的一种新型乳液,较传统的表面活性剂稳定的乳剂,具有更好的热力学稳定性,且低毒,对环境友好,近年来受到广泛关注。笔者从Pickering乳液的稳定理论、Pickering乳液的固体微粒、Pickering乳液在药剂学的应用以及新型药物纳米晶自稳定Pickering乳液的研究等4个方面,就近年来Pickering乳液在药剂学的研究进展进行综述,以期为开发基于Pickering乳液的新型药物制剂提供参考。Pickering emulsions stabilized by solid microparticles, having the advantages of strong interfacial stability, non-toxicity and eco-friendliness compared with the traditional surfactant-stabilized emulsions, have been the focus of considerable researches in recent years. In this review, the application studies on Pickering emulsions were summarized from the following aspects：the stabilization theory about Pickering emulsions, solid microparticles used in Pickering emulsions, the applications of Pickering emulsions in pharmaceutical field and the new Pickering emulsion stabilized by drug nanocrystalline itself. These research progress would promote and expand the application of Pickering emulsions in pharmaceutical field.

关 键 词：Pickering乳液 固体微粒 乳化剂 

分 类 号：R944[医药卫生—药剂学]