培菲康联合锌制剂治疗婴幼儿肺炎继发性腹泻的临床疗效  

Clinical efficacy of bifico combined with preparation of zinc in treating infantile diarrhea secondary to pneumonia

作　　者：顾晓明 

机构地区：[1]无锡市第八人民医院药剂科,江苏省214011

出　　处：《江苏医药》2016年第19期2129-2131,共3页Jiangsu Medical Journal

摘　　要：目的观察培菲康联合锌制剂治疗婴幼儿肺炎继发性腹泻的临床效果。方法肺炎继发性腹泻的婴幼儿68例随机均分为两组,在规范化抗生素治疗的同时,对照组采用培菲康散剂治疗,联合组给予培菲康散剂加服无糖型赖氨葡锌颗粒。测定患儿治疗前及治疗后72h血浆二胺氧化酶活性及D-乳酸水平,比较两组疗效。结果治疗72h,两组患儿血浆二胺氧化酶活性和D-乳酸水平均较治疗前降低(P<0.05),且联合组低于对照组[(1.06±0.35)U/ml vs.(1.41±0.47)U/ml和(24.31±12.40)μg/ml vs.(32.68±15.44)μg/ml](P<0.05)。联合组总有效率为91.18%,高于对照组的73.53%(P<0.05)。结论在规范化抗生素治疗的基础上,加用培菲康和锌制剂是治疗婴幼儿肺炎继发性腹泻的有效方法。Objective To observe the efficacy of bifico combined with preparation of zinc in treating infantile diarrhea secondary to pneumonia .Methods Sixty-eight infants with diarrhea secondary to pneumonia were equally randomized into two groups ,who were treated standardizedly with antibiotics .The infants in group A were treated with oral bifico combined with preparation of zinc and those in group B were treated with oral bifico .Plasma levels of diamine oxidase and D-lactic acid were detected before and at 72 hours after treatment .The efficacy was compared between two groups . Results Plasma levels of diamine oxidase and D-lactic acid were significantly lower after treatment than those before ,which were lower in group A than those in group B[（1.06 ± 0.35） U/ml vs .（1.41 ± 0.47） U/ml and （24.31 ± 12.40） μg/ml vs .（32.68 ± 15.44） μg/ml]（P〈0 .05） .The overall effectiveness rate was higher in group A than that in group B （91.18% vs .73.53% ）（P〈0 .05） . Conclusion On the basis of standardized antibiotics therapy ,combined use of oral bifico and zinc preparation is effective in the treatment of infantile diarrhea secondary to pneumonia .

关 键 词：培菲康 锌 婴幼儿腹泻 肺炎 

分 类 号：R725[医药卫生—儿科]