替罗莫司的制备及其抗肿瘤活性研究进展  

Preparation and anticancer activity of temsirolimus:research advances

作　　者：赵艳艳[1] 梁旭华[1] 何念武[1] 程敏[1] 

机构地区：[1]商洛学院生物医药与食品工程学院,商洛726000

出　　处：《国际药学研究杂志》2016年第5期824-828,共5页Journal of International Pharmaceutical Research

基　　金：陕西省教育厅专项科研计划项目(16JK1242);商洛市科技计划项目(SK2015-36);商洛市食品药品监督管理局项目(SFK2016-01-04)

摘　　要：近年来,尽管抗肿瘤药物的研究取得了很大进展,恶性肿瘤仍是严重危害人类健康的主要疾病。寻找疗效高、毒副作用小的药物,一直是抗肿瘤药物研发的重点。本文着重从抗癌药物替罗莫司的理化性质、制备过程、抗肿瘤作用机制、临床疗效、毒副作用及其主要异构体等方面进行综述,为其进一步开发应用提供有益的线索。Notwithstanding the noteworthy advances in its treatment,malignant tumor remains one of the main diseases threat-ening human health. Therefore,it is urgent to search and develop novel anticancer drugs with high curative effect and less side effect. In this review,we focus on summarizing the physio-chemical properties,preparation processes,anti-tumor activity mechanisms,clini-cal effects,side effects,and main isomers,especially the research progress of temsirolimus,with the hope to provide some reference for the further research.

关 键 词：西罗莫司 替罗莫司 抗肿瘤活性 

分 类 号：R943[医药卫生—药剂学] R96[医药卫生—药学]