抗突变型瓜氨酸波形蛋白抗体检测对类风湿关节炎的辅助诊断作用  

The clinical application of detecting the anti-mutated citrullinated vimentin antibody in the diagnosis of rheumatoid arthritis

作　　者：魏萍[1] 王艳侠[1] 王敏 石书梅[1] 

机构地区：[1]济南军区总医院肾内科肾病实验中心,山东济南250031 [2]济南市历城区计划生育服务站,山东济南250100

出　　处：《实用医药杂志》2016年第10期874-876,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的通过与抗环瓜氨酸肽(CCP)抗体、类风湿因子(RF)比较,评估抗突变型瓜氨酸波形蛋白(MCV)抗体检测在类风湿关节炎(RA)中的临床应用价值。方法对222例研究对象,包括132例RA患者,42例非RA的风湿性疾病患者及48名健康对照组,应用酶联免疫吸附试验(ELISA)检测血清中的抗MCV抗体水平,并同时检测血清中抗CCP抗体、RF水平。统计学分析采用t检验和χ2检验。结果 132例RA中抗MCV抗体阳性97例,对RA诊断的敏感性为73.5%,特异性为94.4%,阳性预测值和阴性预测值分别为95.1%和70.8%。结论抗MCV抗体在RA中具有较高的敏感性和特异性,可作为RA诊断的辅助指标,建议抗MCV抗体和抗CCP抗体联合检测,可提高对RA诊断的特异性,提高早期诊断率。Objective To investigate the prevalence and clinical significance of anti-mutated citrullinated vimentin antibodies （anti-MCV） in rheumatoid arthritis through comparing it with anti-cyclic citrullinated peptide antibodies and rheumatoid factors. Methods Anti-MCV antibody was tested by enzyme-linked immunosorbent assay （ELISA） in 220 serum samples including 132 patients with RA,42 sujects with out non-RA rheumatic diseases and 48 healthy controls. Results Anti-MCV was found 97 in RA. The sensitivity and specificity of anti-MCV in RA were 73.5% and 94.4%. The positive and negative predictive value were 95.1% and 70.8%. Conclusion Anti-MCV antibody may be an valuable parameter for the diagnosis of RA .The anti-MCV and anti-CCP antibody are advised to co-test to improve specificity and the early diagnosis rate of RA.

关 键 词：关节炎 类风湿 抗突变型瓜氨酸波形蛋白抗体 抗环瓜氨酸肽抗体 类风湿因子 

分 类 号：R392.3[医药卫生—免疫学] R593.22[医药卫生—基础医学]