小RNA对胞内菌生长、毒力及铁水平的调节作用  

Regulatory role of small RNA in intracellular bacterial growth,virulence and iron level

作　　者：吴铮[1] 李文静[1] 李爱梅[1] 付英梅[1] 张凤民[1] WU Zheng LI Wenjing LI Aimei FU Yingmei ZHANG Fengmin(Department of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin 150081, China)

机构地区：[1]哈尔滨医科大学微生物学教研室,伍连德研究所,黑龙江省免疫与感染重点实验室,黑龙江省普通高校病原生物学重点实验室,哈尔滨150081

出　　处：《微生物与感染》2016年第5期302-306,共5页Journal of Microbes and Infections

基　　金：国家自然科学基金(J1103609、J1210062、31370164、811013000)

摘　　要：细菌小RNA（small RNA,sRNA）是一类长度为50-500个碱基,具有调控转录、翻译和mRNA稳定性的非编码调节性RNA。随着越来越多的sRNA被鉴定,部分细菌的sRNA功能已逐步阐明,主要参与调控细菌的基因表达、增殖、毒力及对环境的应激反应等生物学过程。本文就胞内菌（如沙门菌、李斯特菌、嗜肺军团菌等）sRNA对其自身在宿主细胞内的生长、毒力和铁水平的调控作用进行综述。Small RNA（sRNA）is a class of non-coding RNA of 50-500 bases with a regulatory function on transcription,translation and mRNA stability.Bacterial sRNAs have been implicated in gene expression,cellular proliferation,virulence and adaptation to environmental conditions.The role of sRNAs in intracellular infection（such as Salmonella,Listeria,Legionella pneumophia,etc.）,including the regulation on growth,virulence and host iron levels is reviewed in this paper.

关 键 词：细菌 小RNA 胞内菌 毒力 生长 

分 类 号：R378[医药卫生—病原生物学]