畲药搁公扭根化学成分研究  

Chemical constituents of traditional She medicine Rubi Radix et Rhizoma

作　　者：姜程曦[1] 毛菊华 王伟影 程文亮 程科军[1,3] 

机构地区：[1]温州医科大学药学院,浙江温州325035 [2]丽水市食品药品与质量技术检验检测院,浙江丽水323000 [3]丽水市农业科学研究院,浙江丽水323000

出　　处：《中草药》2016年第19期3370-3373,共4页Chinese Traditional and Herbal Drugs

基　　金：浙江省重大专项(2012C12014-1);丽水市科技项目(20140212037;2014JYZB04)

摘　　要：目的对畲药搁公扭根Rubi Radix et Rhizoma(蔷薇科植物华东覆盆子Rubus chingii的根及根茎)中的化学成分进行研究。方法采用各种色谱法分离纯化,并结合理化常数和光谱分析等鉴定化合物的结构。结果从搁公扭根95%乙醇提取物中共分离得到9个化合物,分别鉴定为β-谷甾醇(1)、胡萝卜苷(2)、蔷薇酸(3)、11α-羟基蔷薇酸(4)、委陵菜酸(5)、鞣花酸(6)、没食子酸(7)、熊果酸(8)、齐墩果酸(9)。结论所有化合物均为首次从畲药搁公扭根中分离得到,其中化合物4为首次从华东覆盆子中分离得到。Objective To explore the chemical constituents oflraditional She medicine Rubi Radix et Rhizoma （the roots and rhizomes of Rubus chingii in family Rosaceae）. Methods The compounds were isolated and purified by various column chromatography and the structures were identified by physicochemical constant determination and spectral analysis. Results Nine compounds were isolated and identified as 13-sitosterol （1）, daucosterol （2）, euscaphic acid （3）, i lct-euscaphic acid （4）, tormentic acid （5）, ellagic acid （6）, gallic acid （7）, ursolic acid （8）, and oleanolic acid （9） from 95% ethanol extract of Rubi Radix et Rhizoma. Conclusion All the nine compounds are isolated from Rubi Radix et Rhizoma for the first time and the compound 4 is first isolated from R. chingii.

关 键 词：畲药 搁公扭根 覆盆子 蔷薇酸 11α-羟基蔷薇酸 

分 类 号：R284.1[医药卫生—中药学]