防己黄芪汤药理作用及各单味药化学成分研究进展  

Research progress in chemical constituents in single herbs of Fangji Huangqi Decoction and its pharmacological activities

作　　者：汪小莉[1,2] 刘晓[1,2] 夏春燕[1] 祝婷婷[1,2] 朱慧[1,2] 蔡宝昌[1,2] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]南京中医药大学国家教育部中药炮制规范化及标准化工程研究中心,江苏南京210023

出　　处：《中草药》2016年第19期3527-3534,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金青年基金项目(81503207)

摘　　要：防己黄芪汤是由防己、黄芪、白术和炙甘草组成的临床常用方剂。目前研究发现该方中主要含有生物碱类、皂苷类、黄酮类和内酯类等化学成分。药理研究表明该方具有治疗慢性肾小球肾炎、肾病综合征、肾水肿和心脏水肿等功效。从古方来源及现代研究的不同层次,综述其主要的化学成分及药理作用的研究进展,为防己黄芪汤及相关组方的药效物质基础研究提供参考。Fangji Huangqi Tang is a traditional Chinese medicine formula composed of Stephaniae Tetrandrae Radix, Astragali membranaceus Radix, Atractylodis Macrocephale Rhizoma, and Glycyrrhizae Radix et Rhizoma Praeparata cure Melle. At present, the compounds extracted from the Chinese materia medica in Fangji Huangqi Decoction are reported to be alkaloids, flavonoids, saponins, saccharides and terpenoids. Fangji Huangqi Decoction was identified as one of the main formula used to treat chronic glomerular nephritis, nephrotic syndrome, renal edema, and cardiac edema in clinical application of traditional Chinese medicine. In this paper, the research progress in the chemical constituents and their pharmacologic actions of Fangji Huangqi Decoction are reviewed, providing the scientific basis for its modernization research and comprehensive utilization.

关 键 词：防己黄芪汤 防己 黄芪 白术 炙甘草 生物碱 皂苷 黄酮 

分 类 号：R282.71[医药卫生—中药学]