养阴通络汤联合舌三针治疗缺血性中风后失语症阴虚风动证疗效观察  

Effect of Yangyin Tongluo Decoction Combined with Tongue Triple Acupuncture in Treating Aphasia After Ischemic Stroke with Syndrome of Yin Deficiency and Wind Stirring

作　　者：陈睿[1] 孙苏闻 周睿娴[1] 王光义[1] CHEN Rui SUN Su-wen ZHOU Rui-xian WANG Guang-yi(The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China)

机构地区：[1]贵州医科大学附属医院,贵阳550001

出　　处：《中国实验方剂学杂志》2016年第20期148-152,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目

摘　　要：目的:观察养阴通络汤联合舌三针治疗缺血性中风后失语症阴虚风动证的疗效,及对血清降钙素基因相关肽(CGRP)和血管内皮素(ET)水平的影响。方法:筛选缺血性中风后失语症患者共98例,按数字表法随机分为对照组(48例)和治疗组(50例);两组依据《中国脑血管病防治指南》行常规治疗;对照组应用舒尔氏(Schuell)刺激法行言语康复训练,30min/次,3次/周;治疗组在对照组基础上采取养阴通络汤(1剂/d,分早晚2次温水冲服)联合舌三针治疗(1次/d,5次/周);两组均连续治疗30 d。比较两组患者言语功能、中医(TCM)阴虚风动证相关症状评分及临床疗效;检测两组血清CGRP和ET水平。结果:治疗后,治疗组中国康复研究中心失语症检查表(CRRCAE)各项指标评分均明显高于对照组,TCM评分显著低于对照组(P<0.01);治疗组愈显率明显高于对照组(P<0.05);治疗后15,30 d,治疗组血清CGRP水平显著高于对照组同时间点,ET低于对照组(P<0.01)。结论:在常规西医治疗基础上,养阴通络汤联合舌三针能够显著改善阴虚风动型缺血性中风后失语症的言语功能、中医症状,提高临床疗效,上调患者血清CGRP水平及抑制ET水平可能与其治疗作用密切相关。Objective： To observe the effect of Yangyin Tongluo decoction combined with tongue triple acupuncture in treating aphasia after ischemic stroke with syndrome of Yin deficiency and Wind stirring,and the impact on serum calcitonin gene-related peptide（ CGRP） and endothelins（ ET）. Method： Ninety-eight cases with aphasia after ischemic stroke were divided into control group（ 48 cases） and treatment group（ 50 cases） by table of random number method. The conventional therapy was given to all of the patients according to China Cerebrovascular Disease Prevention and Treatment Guidelines. Patients in control group were treated with Schuell＇s aphasic stimulation approach,30 min/time,3 times/week. In addition to the therapy of control group,treatment group was also given Yangyin Tongluo decoction（ one dose/d,bid） combined with tongue triple acupuncture（ qd,5 times/week）. The treatment courses for all of the cases were 30 days. Speaking function,clinical efficacy and scores of traditional Chinese medicine（ TCM） symptom were evaluated and compared between both groups. Serum CGRP and ET in both groups were evaluated. Result： After treatment,each index score in Chinese rehabilitation research center aphasia examination（ CRRCAE） in treatment group was obviously higher those of control group,but with obviously lower TCM scores（ P〈0. 01）. The cured and markedly effective rate of treatment group was superior to that of control group（ P〈0. 05）. Treatment group showed a higher serum level of CGRP,but lower ET than that of control group at the same time points at 15 and 30 d after treatment（ P〈0. 01）. Conclusion： In addition to the conventional western medicine therapy,Yangyin Tongluo decoction combined with tongue triple acupuncture in treating with aphasia after ischemic stroke with syndrome of Yin deficiency and wind stirring improves language function,TCM symptom scores and clinical efficacy. Up-regulation in levels of CGRP and inhibition of ET may be closely related with

关 键 词：养阴通络汤 舌三针 缺血性中风 失语症 阴虚风动证 

分 类 号：R287[医药卫生—中药学]