中西医结合治疗婴儿巨细胞病毒肝炎临床疗效及安全性Meta分析  

Meta-analysis on Efficacy and Safety of Integrated Traditional Chinese and Western Medicine Therapy for Infantile Cytomegalovirus Hepatitis

作　　者：李维薇[1] 杨燕[2] 谢辉辉[1] 汪受传[1] LI Wei-wei YANG Yan XIE Hui-hui WANG Shou-chuan(The First Clinical Medical Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China Beijing Children＇s Hospital, Capital Medical University, Beijing 100045, China)

机构地区：[1]南京中医药大学第一临床医学院,南京210029 [2]首都医科大学附属北京儿童医院,北京100045

出　　处：《中国实验方剂学杂志》2016年第20期178-182,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81473725);北京市卫生系统高层次卫生技术人才培养计划项目(2013-2-012)

摘　　要：目的:评价中西医结合治疗婴儿巨细胞病毒(cytomegalovirus,CMV)肝炎的临床疗效及安全性。方法:对中国知网数据库,维普中文科技期刊数据库,中国生物医学文献数据库,万方数据库,Pubmed,Cochrane图书馆进行检索。收集有关中西医结合治疗婴儿CMV肝炎的随机对照试验(randomized controlled trial,RCT),根据纳入和排除标准收集文献,进行Meta分析。结果:共纳入12篇RCT,Meta分析结果显示中西医结合治疗该病在总有效率、改善肝功能、促进肝脏回缩以及CMV病毒指标转阴率方面优于对照组。结论:中西医结合治疗婴儿CMV肝炎疗效优于单纯西医治疗,但纳入文献方法学质量普遍偏低,亟需更多高质量的临床试验进一步验证。Objective： To evaluate the clinical effects and safety of integrated traditional Chinese and western medicine for infantile CMV hepatitis. Method： Electronic databases of CNKI,VIP,CBM,Wanfang,Pubmed and Cochrane Library were searched to collect randomized controlled trials（ RCTs） of infantile CMV hepatitis. The literatures were screened out according to inclusion and exclusion criteria,and then put into a Metaanalysis. Result： In this study,totally 12 trials were included. According to the Meta-analysis,the treatment group was superior to the control group in evident increases in total effective rate,improvement rate of liver function,promotion of liver retraction to normal,and negative rate of CMV-Ig M and CMV-DNA. Conclusion：Compared with western medicine,integrated traditional Chinese and western medicine is superior in treating infantile CMV hepatitis. However,due to the low methodological quality of included trials,more high-quality RCT are required for further verification.

关 键 词：婴儿巨细胞病毒肝炎 中西医结合 随机对照试验 META分析 

分 类 号：R287[医药卫生—中药学]