基于关联规则和复杂系统熵聚类的刘持年教授治疗慢性胃炎的用药规律  

Professor LIU Chi-nian's Prescription Experience for Chronic Gastritis Based on Association Rules and Complex System Entropy Cluster Algorithm

作　　者：李茜[1] 李晓阳[1] 黄伟[2] LI Qian LI Xiao-yang HUANG Wei(Shandong University of Traditional Chinese Medicine, Ji＇nan 250355, China Shandong Academy of Chinese Medicine, Ji＇nan 250014, China)

机构地区：[1]山东中医药大学,济南250355 [2]山东省中医药研究院,济南250014

出　　处：《中国实验方剂学杂志》2016年第20期183-188,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山东省自然科学基金项目(ZR2015HM056)

摘　　要：目的:基于中医传承辅助平台(V2.5)软件,分析刘持年教授治疗慢性胃炎的用药经验。方法:收集刘持年教授治疗慢性胃炎的处方,录入中医传承辅助平台,采用该软件集成的规则分析、改进互信息法等数据挖掘方法,分析刘持年教授治疗慢性胃炎的用药经验。结果:对筛选出的125首处方进行分析,确定处方中药物的使用频次及药物之间的关联规则,挖掘出高频药物,常用药物组合,12个核心组合和6首新处方。结论:刘教授认为,慢性胃炎多在脾胃虚弱的基础上而发,虚多于实,虚证贯穿于整个病理过程。治疗上以健脾养胃、益气养阴为主,同时注重升降并调,清补并举以调畅气机,理气和胃。中医传承辅助平台对于分析名老中医处方用药规律具有实用性、客观性,对科学全面地总结名老中医的临床经验具有重要的价值。Objective： To analyze the prescription experience of professor LIU Chi-nian for treating chronic gastritis（ CG） by using Traditional Chinese Medicine Inheritance Support System（ TCMISS）. Method：The prescriptions for chronic gastritis（ CG） were collected,and then the data was input into the TCMISS to analyze the prescription experience of professor LIU Chi-nian by using data mining methods,such as improved mutual information,complex system entropy cluster and unsupervised hierarchical cluster. Result： Based on the analysis of 125 prescriptions,the frequency of herbs used in prescriptions and the association rules among the herbs were determined, and the frequently-used herbs, commonly-used herbs,12 core combinations and 6 new prescriptions were mined from the database. Conclusion： Professor LIU Chi-nian considered chronic gastritis（ CG） mostly occurs with the weakness of the spleen and the stomach. Deficiency syndrome runs through the whole pathological process. The therapy shall focus on nourishing the stomach and spleen, supplementing Qi and nourishing yin. In addition,professor LIU Chi-nian laid emphasis on regulating the ascending and descending of Qi activity,and adopted clearing therapy and tonic therapy at the same time to regulate Qi and harmonizing the stomach. TCMISS is practical and objective to analyze the famous TCM doctor＇ clinical prescription experience,with great value in making a comprehensive summary of the clinical experience.

关 键 词：刘持年 慢性胃炎 用药规律 关联规则 复杂系统熵聚类 中医传承辅助平台 

分 类 号：R287[医药卫生—中药学]