多穗金粟兰乌药烷型倍半萜二聚体类化学成分研究  

Chemical constituents in lindenane-type sesquiterpene dimers in roots of Chloranthus multistachys

作　　者：林凤祥[1] 罗永明[1] 李宏焘 张丽[1] 张珊珊[1] 陈怀远[1] 

机构地区：[1]江西中医药大学药学院,江西南昌330004

出　　处：《中草药》2016年第18期3169-3174,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(21262019);江西省高等学校科技落地计划项目(KJLD13064)

摘　　要：目的对金粟兰属植物多穗金粟兰Chloranthus multistachys根部乙醇提取物的化学成分进行研究。方法利用多种色谱技术进行分离纯化,通过理化性质和波谱数据鉴定化合物结构。结果从多穗金粟兰的氯仿和醋酸乙酯提取物中分离得到12个乌药烷型倍半萜二聚体,鉴定其结构为环银线草醇A-9-O-β-葡萄糖苷（1）、环银线草醇A（2）、银线草醇B（3）、银线草醇C（4）、银线草醇D（5）、银线草醇F（6）、银线草醇G（7）、多穗金粟兰醇B（8）、草珊瑚内酯B（9）、sarglabolide I（10）、8-O-methyltianmushanol（11）、henriol B（12）。结论化合物1、7、9~12为首次从该植物中分离得到,化合物9和10为首次从金粟兰属植物中分离得到。Objective To study the chemical constituents contained in the ethanol extracts from the roots of Chloranthus multistachys. Methods Twelve compounds were separated from the roots of C. multistachys and their structures were identified by using various chromatographic techniques. Results The structures of the 12 lindenane-type sesquiterpene dimmers from the chloroform and ethyl acetate extract in the roots of C. multistachys were identified on the basis of physicochemical properties and spectral data as 9-O-β-glucopyranosylcycloshizukaol A（1）, cycloshizukaol A（2）, shizukaol B（3）, shizukaol C（4）, shizukaol D（5）, shizukaol F（6）, shizukaol G（7）, chloramultiol B（8）, sarcandrolide B（9）, sarglabolide I（10）, 8-O-methyltianmushanol（11）, and henriol B（12）. Conclusion Compounds 1, 7, and 9—12 are isolated from the roots C. multistachys for the first time and compounds 9 and 10 are obtained from the plants of Chloranthus Sw. for the first time.

关 键 词：多穗金粟兰 乌药烷型 倍半萜二聚体 草珊瑚内酯B sarglabolide I henriol B 

分 类 号：R284.1[医药卫生—中药学]