苯醚甲环唑中间体二芳醚缩酮的制备工艺研究  

Study on the Oxidation of Cyclohexanol to Cyclohexanone

作　　者：吴翔[1] 马勇[1] 王秋萍[1] 石苏洋 

机构地区：[1]江苏扬农化工集团有限公司,江苏扬州225009

出　　处：《广东化工》2016年第19期61-62,共2页Guangdong Chemical Industry

摘　　要：以对甲苯磺酸为催化剂,催化2-氯-4-(4-氯苯氧基)-苯乙酮与1,2-丙二醇环化制备苯醚甲环唑中间体二芳醚缩酮,考察了反应时间、反应物浓度、催化剂用量、原料配比对环化反应的影响。最优工艺条件为:反应物浓度为低于33 wt%,催化剂用量为2.6 wt%,反应时间为5 h,2-氯-4-(4-氯苯氧基)-苯乙酮与丙二醇摩尔配比1∶1.2,2-氯-4-(4-氯苯氧基)-苯乙酮的转化率达到99.58%。中间体二芳醚缩酮可进一步进过溴化、合成、成盐、固化制备苯醚甲环唑。In the paper, the synthesis on Intermediate of difenoconazole from 2-chloride-4-（4-chlorophenoxy）-phenyl ethyl ketone and 1,2-propanediol was studied. The influences of reaction time, reactant concentration, the amount of catalyst and the ratio of raw materials were investigated. The results demonstrated that the optimum reaction conditions were reaction time was 5hr, reactant concentration was 33 wt%, amount of catalyst was 2.6 wt%, molar ratio of 2-chloride-4-（4-chlorophenoxy）-phenyl ethyl ketone and 1,2-propanediol was 1∶1.2. The conversion of 2-chloride-4-（4-chlorophenoxy）-phenyl ethyl ketone was 99.58 %. Difenoconazole can be synthesized through bromination, synthesis, salification and solidification.

关 键 词：2-氯-4-(4-氯苯氧基)-苯乙酮 1 2-丙二醇 对甲苯磺酸 苯醚甲环唑 

分 类 号：TQ[化学工程]