聚NVP-DVB单分散共聚微球的制备及其应用研究  

Preparation of Poly(NVP-DVB) Monodisperse Copolymer Microspheres and Application in Solid Phase Extraction

作　　者：周丽[1] 李海涛[1] 

机构地区：[1]天津博纳艾杰尔科技有限公司,天津300462

出　　处：《广东化工》2016年第20期80-82,共3页Guangdong Chemical Industry

摘　　要：以二乙烯苯（DVB）、N-乙烯基吡咯烷酮（NVP）、丙烯酸甲酯（MA）、甲基丙烯酸甲酯（MMA）为共聚单体,采用种子溶胀聚合法合成了一系列聚NVP-DVB单分散共聚微球。采用扫描电镜和比表面测定仪对共聚微球进行了表征。同时以3种性质不同的化合物为模型,采用SPE-HPLC对自制的共聚填料进行了系统的评价,并应用于化妆品中糖皮质激素的检测分析。结果表明：2#共聚微球对三种化合物的回收率在95.24%~100.53%之间,优于其它共聚微球;NVP-DVB用于对膏状化妆品（护手霜）中的11中糖皮质激素进行检测,回收率和相对偏差均符合生物样品分析要求。Poly（NVP-DVB） monodisperse copolymer microspheres were synthesized by seed swelling polymerization,using divinyl benzene（DVB）, N-vinyl pyrrolidone（NVP）, methyl acrylate（MA） and methyl methacrylate（MMA） as monomer。Its performance was evaluated using scanning electron microscopy（SEM）、specific surface and three model compounds having different polarities in SPE-HPLC. The results show that 2# copolymer had high recoveries for the three compounds ranging from 95.24 % to 100.53 % which were better than the other compounds. In applying to detect 11 of glucocorticoids in cosmetics, recovery and the relative deviation are conform to the requirements of biological sample analysis.

关 键 词：N-乙烯基吡咯烷酮 种子溶胀聚合 二乙烯苯 固相萃取 化妆品 

分 类 号：TQ[化学工程]