泰妙菌素生产过程中截短侧耳素制备工艺研究  

Study on Preparation Technology of Pleuromutilin in the Production Process of Tiamulin

作　　者：刘媛媛[1,2] 沈志鸿[1,2] 段旭飞 伦飞[1,2] 薛佳伟[1] 郭立达[1] 

机构地区：[1]河北工业职业技术学院环境与化学工程系,石家庄050091 [2]华北理工大学化学工程学院,唐山063000

出　　处：《价值工程》2016年第25期190-191,共2页Value Engineering

基　　金：河北工业职业技术学院大学生课题(自然科学类)资助项目(No.XZZ201605)

摘　　要：为解决企业合成泰妙菌素所遇到的原料截短侧耳素质量和产品收率等实际问题，研究采用甲基异丁基酮浸提法，充分去除杂质，获得高质量的基础原料，进而在适合配比浓度的反应条件下，经过磺化反应、硫化反应、成盐得到泰妙菌素成品。以年产2000吨的泰妙菌素计算，每年可以提高产量10-20%，并且消除约上万吨废弃物的排放，产生数千万的经济效益。In order to solve the actual problem of pleuromutilin quality and product yield in tiamulin composition, this paper proposes to use methyl isobutyl ketone extraction to fully remove impurities, and obtain high quality basic raw materials, and then get Tiamulin at a suitable concentration ratio of the reaction conditions after sulfonation reaction, sulfurization reaction, salt formation. Calculated with an annual output of 2,000 tons tiamulin per year, the production can be increased from 10 to 20 percent and thousands of tons of waste emissions can be eliminated, resulting in tens of millions of economic benefits.

关 键 词：泰妙菌素 截短侧耳素 甲基异丁基酮浸提法 

分 类 号：TQ021.8[化学工程]