定量CT研究中老年男性椎后肌群退行性改变与年龄的相关性  

Relationships between the spine muscle degenerative changes and the aging in elderly males by quantitative computed tomograph

作　　者：蔡韦[1] 王玲[1] 陈颐中 焦顺霞 赵茜[3] 李新彤[1] 端木羊羊 王晨[1] 侯雪[1] 程晓光[1] 

机构地区：[1]北京积水潭医院放射科,北京100035 [2]四川省大邑县人民医院放射科,成都611330 [3]华西医院/华西临床医学院全科医学科,成都610041 [4]安徽医科大学附属第四医院放射科,合肥230032

出　　处：《重庆医学》2016年第30期4193-4196,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(81401407);北京市卫计委首都医学发展科研基金资助项目(首发2014-2-1122);北京市卫生局"215"高层次卫生技术人才培养计划基金资助项目(2009-2-03)

摘　　要：目的研究健康中老年男性椎后肌群的脂肪浸润及肌肉含量与腹内脂肪及年龄的相关关系。方法使用定量CT（QCT）检测88名50-79岁健康男性L3腰椎中部层面椎后肌群的脂肪面积、肌肉面积、肌肉脂肪浸润（MFI）比例情况及腹部多层面内脏脂肪面积、皮下脂肪面积、总脂肪面积,并计算出腹部总内脏脂肪含量、腹部总皮下脂肪含量和腹部总脂肪含量。统计学处理应用组内相关系数、方差分析及Bonferroni分析、Pearson相关分析和多元逐步回归分析。结果高龄组（70-79岁）的MFI和肌量变化的程度明显高于另两组（P〈0.05）。椎后肌群的脂肪面积及MFI程度与年龄有弱相关性（其中脂肪面积：r=0.381,P〈0.05;MFI：r=0.358,P=0.001）,但肌肉含量的改变与年龄没有显著相关性。年龄是唯一进入全部椎后肌群体质成分的回归方程的影响因素。结论在健康中老年男性人群中,年龄增长是影响椎后肌群退变进程的重要因素,而椎后肌群的MFI程度与衰老导致的骨骼肌退变密切相关。Objective To explore the age related decline in spine muscle volume and fat content in healthy elderly males.Methods Totally 88 males aged 50-79 years were selected from the patients who underwent quantitative CT（QCT）exam of lumbar spine.They were subgrouped by 50-60years,60-70years and 70-79 years.The muscle fat area,skeletal muscular area,muscle fat infiltration（MFI）,abdominal visceral fat volume and subcutaneous fat volume,abdominal total fat volume were measured by the QCT software.Statistical analysis was performed using intraclass correlation coefficient,ANOVA with post hoc Bonferroni correction,Pearson correlation analysis and multiple regression analysis.Results Compared to other two groups,subjects in 70-79 years subgroup had highest muscle fat area/MFI and least skeletal muscular mass（P〈0.05）.Age-dependent correlation was found in muscle fat mass（r=0.381,P〈0.05）and MFI（r=0.358,P=0.001）,but no obvious correlation was found between age and skeletal muscular mass.Age was the only factor entered into the all three paravertebral muscle composition regression equations,meaning age may had an important influence on paravertebral muscle degeneration.Conclusion Lumbar paravertebral muscle degeneration in elderly men is correlated with the aging and MFI,which may play a important role in the normative age-related decline of skeletal muscle.

关 键 词：椎后肌群 退行性变 脂肪浸润 定量CT 

分 类 号：R681[医药卫生—骨科学] R816.8[医药卫生—外科学]