共振能量转移分子显像在生物医学中的应用  

Resonance Energy Transfer Molecular Imaging Application in Biomedicine

作　　者：聂大红[1,2] 唐刚华[1,3] 

机构地区：[1]中山大学附属第一医院广东省医用放射性药物转化应用工程技术研究中心,广东广州510080 [2]中山大学附属第一医院放疗科,广东广州510080 [3]中山大学附属第一医院核医学科,广东广州510080

出　　处：《同位素》2016年第4期248-256,共9页Journal of Isotopes

基　　金：国家自然科学基金项目(81371584;81571704)

摘　　要：共振能量转移分子显像(RETI)能显著改善光信号强度和组织穿透性,可用于活体深度组织光学显像。共振能量转移(RET)是指发生在近距离的供体与受体之间的能量转移,包括非放射共振能量转移和放射共振能量转移。RETI是基于共振能量转移的光学成像技术,主要包括荧光共振能量转移显像(FRETI)、生物发光共振能量转移显像(BRETI)、化学发光共振能量转移显像(CRETI)和放射共振能量转移显像(RRETI)。目前,RETI是分子显像研究的热门领域,已用于生物医药学研究各领域。本文对RETI技术原理及其在生物医学中的应用进行综述。Resonance energy transfer molecular imaging （RETI） can markedly improve signal intensity and tissue penetrating capacity of optical imaging, and have huge poten-tial application in the deep-tissue optical imaging in vivo. Resonance energy transfer （RET） is an energy transition from the donor to an acceptor that is in close proximity, including non-radiative resonance energy transfer and radiative resonance energy trans-fer. RETI is an optical imaging technology that is based on RET. RETI mainly contains fluorescence resonance energy transfer imaging （FRETI） , bioluminescence resonance energy transfer imaging （BRETI）, chemiluminescence resonance energy transfer imaging （CRETI） , and radiative resonance energy transfer imaging （RRETI）. RETI is the hot field of molecular imaging research and has been widely used in the fields of biology and medicine. This review mainly focuses on RETI principle and application in biomedicine.

关 键 词：共振能量转移分子显像 荧光共振能量转移 生物发光共振能量转移 化学发光共振能量转移 放射共振能量转移 

分 类 号：R817.4[医药卫生—影像医学与核医学]