静脉注射免疫球蛋白治疗新生儿ABO血型不合溶血病的剂量探讨  

The adequate dose of introvenous immunoglobulin in treating ABO hemolytic disease of the newborn

作　　者：王明月[1] 王念亮[2] 王凯[3] 牟春笋[1] 于宝妹[1] 葛明[1] 沈德炜[1] 

机构地区：[1]济南铁路中心医院,山东济南250001 [2]济南市妇幼保健院,山东济南250001 [3]济南市中心医院,山东济南250013

出　　处：《现代医学》2002年第4期230-232,共3页Modern Medical Journal

摘　　要：目的　探讨静脉注射免疫球蛋白 (IVIG)治疗新生儿ABO血型不合溶血病 (ABO HDN)的适宜剂量。方法　将46例ABO HDN随机分为两组 ,每组 2 3例。在给予蓝光、清蛋白、酶诱导剂等常规治疗基础上 ,加用IVIG ,大剂量组每日40 0～ 6 0 0mg·kg-1,连用 3d ;超大剂量组每日 10 0 0mg·kg-1,连用 2d。结果　两组治疗 5d后血清总胆红素分别为( 133.14± 34.36 ) μmol·L-1、( 12 7.39± 2 8.6 1) μmol·L-1;治疗 7d后经皮胆红素指数分别为 15 .35± 1.47、14 .6 7± 1.84;累计光疗时间分别为 ( 4 5 .80± 13.38)h、( 4 8.74± 15 .6 2 )h。两组各项数据经统计学处理均无显著性差异。结论　大剂量和超大剂量静脉注射免疫球蛋白治疗新生儿ABO HDN的疗效相同。Objective To investigate the adequate dose of intravenous immunoglobulin (IVIG) in treating ABO hemolytic disease of the newborn(ABOHDN).Methods 46 cases of ABOHDN were divided into two groups randomly,23 cases in each.Under the basic treatment of blue light,albumin,enzyme-induced drugs,IVIG was used. 400～ 600mg·kg -1 ·d -1 ,for 3 days,in high dose group;and 1000mg·kg -1 ·d -1 ,for 2 days,in super-high dose group.Results After 5 days treatment,the serum bilirubins in two groups were( 133.14±34.36)μmol·L -1 ,( 127.39± 28.61)μmol·L -1 respectively;after 7 days,the percutaneous bilirubin indexes were 15.35±1.47, 14.67± 1.84 respectively;the accumulated radiation time were(45.80±13.38)h,(48.74±15.62)h rspectively.There was no significant difference between the two groups in statistics.Conclusion IVIG has the same effect on treating ABOHDN both in high dose and super-high dose.

关 键 词：静脉注射 免疫球蛋白 治疗 新生儿 ABO血型 溶血病 剂量 IVIG 

分 类 号：R722.18[医药卫生—儿科]