血尿酸水平与代谢综合征及臂踝脉搏波速度的关系  

Relationship of serum uric acid levels and metabolic syndrome and brachial-ankle pulse wave velocity

作　　者：潘伟琦[1] 胡荣[1] 卢燕玲[1] 李曦[1] 于汶[1] 符岚[1] 薛源[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所医院健康管理中心,100029

出　　处：《心肺血管病杂志》2016年第9期724-728,共5页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:探讨血尿酸(SUA)正常高值及高尿酸血症(HUA)与代谢综合征(MS)及臂踝脉搏波速度(bc PWV)的关系。方法:回顾性分析2013年2月至2015年5月,在我院体检的3 022例健康体检者临床资料,依据不同性别SUA水平分为男性HUA组、尿酸正常高值组、尿酸正常低值组及女性HUA组、尿酸正常高值组、尿酸正常低值组;分析各组临床资料、MS相关指标及臂踝脉搏波速度。结果:男性和女性不同SUA组体质量指数(BMI)、SBP、DBP、空腹血糖(FPG)、TC、TG、HDL-C、ba PWV比较,差异有统计学意义(P<0.05)。男性三组MS患病率分别为40.6%、29.8%、10.7%,差异有统计学意义(P<0.05);女性三组MS患病率分别为38.3%、29.9%、9.6%,差异有统计学意义(P<0.05)。分别设男尿酸正常低值组和女尿酸正常低值组MS患病风险为1,经多元Logistic回归分析显示,男尿酸正常高值组和男HVA组与MS患病风险关系差异均有统计学意义(P<0.01),女尿酸正常高值组和女HUA组与MS患病风险关系均差异有统计学意义(P<0.05)。校正年龄、性别,将SUA和MS组分相关指标带入多元线性回归方程为,以ba PWV为因变量,结果显示,ba PWV与SBP、DBP、FPG、TG、SUA具有显著相关性(P<0.05)。结论:SUA持续升高与MS和动脉僵硬度升高有关,而正常高值也可能是MS和动脉僵硬度升高的危险因素。Objective：To investigate the relationship of serum uric acid （SUA） high-normal and hyperuricemia （HUA） and metabolic syndrome （MS） and brachial-ankle pulse wave velocity （PWV）. Methods ： A retrospective analysis, collectedclinical data of 3,022 cases of healthy physical examination from February 2013 to May 2015, depended on the level of SUA and sex into male HUA group, male mid group, male low group and female HUA group, female mid group, female low group, analyzed the clinical data of each group, metabolic syndrome related indexes and bePWV. Results：The difference of male and female different SUA group BMI, SBP, DBP, FPG, TC, TG, HDL-C, baPWV, were statistically significant （P 〈 0. 05）. Male HUA group, male mid group, male low group MS prevalence respectively was 40. 6% , 29.8% , 10. 7%, the difference were statistically significant （ P 〈 0. 05 ） ; female HUA group, female mid group, female low group MS prevalence respectively was 38.3% , 29. 9%, 9.6% , the difference were statistically significant （ P 〈 0. 05 ）. Located malelow group or female low groupMS riskwas 1, by multivariate Logistic regression analysis showed, MS risk in relation male HUA group or male mid group were statistically significant （P 〈0. 01 ） , and MS risk in female HUA group or female mid group was statistically significant relationship （ P 〈 0. 05 ）. After adjusted for age, gender, the SUA and MS components related indicators into the multiple linear regression equation to baPWV as dependent variables, the results show, baPWV and SBP, DBP, FPG, TG, SUA had sig- nificant correlation （P 〈 0. 05）. Conclusion： SUA increased is related to MS and atherosclerosis, whereas the normal high value may also be risk factors for MS and atherosclerosis.

关 键 词：高尿酸血症 代谢综合征 臂踝脉搏波速度 动脉粥样硬化 

分 类 号：R54[医药卫生—心血管疾病]