等离子激元纳米颗粒组装及其生物应用  

Plasmons nanoparticles assembly and biological applications

作　　者：张磊[1] 莫兰[1] 沈晶晶[1] 张颖[1] 汪联辉[1] 

机构地区：[1]南京邮电大学信息材料与纳米技术研究院,有机电子与信息显示国家重点实验室培育基地,先进生物与化学制造协同创新中心,南京210023

出　　处：《科学通报》2016年第27期3036-3048,共13页Chinese Science Bulletin

基　　金：国家重点基础研究发展计划(2012CB933301);国家自然科学基金(61302027,21305070,21475064,61571239);教育部长江学者和创新团队发展计划(IRT_15R37);教育部高校博士点专项基金(20123223120011,20123223110007);江苏高校优势学科建设工程(PAPD);江苏省自然科学基金(BM2012010,NY211003)资助

摘　　要：近年来,通过自组装技术能够可控地将单个纳米颗粒组装成一维、二维或三维空间构象的新型复合材料.相对于单独的纳米颗粒,纳米颗粒组装材料可表现出许多新颖或优异的物理性质,具有巨大的应用前景,因此在纳米材料领域越来越受到关注并快速发展.尤其是贵金属纳米颗粒组装体具有独特的等离子激元光学性质,在生物传感、成像和治疗等方面具有广阔的应用前景.本文回顾了近年来通过分子介导方法对纳米颗粒进行组装及其生物应用的最新研究进展,重点介绍了几种分子介导的纳米颗粒组装技术,以及纳米颗粒组装体的生物医学应用,并展望了其发展前景.Surface plasmon resonance（SPR） effect of nanoparticles, is an emerging subfield of nanophontonics, and it attrac increasing attention because of its potential applications in controlling and manipulating light at nanoscale dimension This review focuses on the molecules mediated nanoparticle assemblies and their biological applications, highligh several molecules mediated nanoparticle assembly technique and their recent applications in biomedical, and prospec the future development. Based on the specific binding ability of these functional mediate molecules（including DNA antigen-antibody, aptamar, biotin-avidin, small organic molecules and polymers）, plasmonic nanoparticles could b synthesized by self-assemble methods. Noble metal nanoparticle assemblies have broad applications in biological sensin imaging and treatment due to their exclusive plasmon optical properties. With the rapid development of self-assembl technology, molecule-mediated self-assembly technology can be used well to control the spatial arrangement structure o plasmonic nanoparticles. Individual nanoparticle has been used to controllable assembled into one-dimensional, two dimensional or three-dimensional conformation of the novel composite materials. SPR effect of noble met nanoparticles, is an emerging subfield of nanophontonics, and it attracts increasing attention because of its potenti applications in controlling and manipulating light at nanoscale dimensions. Compared with the individual nanoparticl nanoparticle assemblies have a lot of novel or excellent physical properties which exhibite convenient adjustable abilit in SPR spectra due to noble metal nanoparticles with irregular shape. They show notable antenna effect at the edge o nanoparticles and the coupling effect between adjacent two nanoparticles. All of these unique optical properties o plasmonic nanoparticles will be further enhanced by the self-assemble nanotechnology, which exhibits many promisin applications in the field of biosensors（including photocolorimetric meth

关 键 词：纳米颗粒 自组装 分子介导 生物应用 

分 类 号：TB383.1[一般工业技术—材料科学与工程]